Updates on Monogenic Obesity in a Multifactorial Disease

Jared Baxter, Priscila Rodrigues Armijo, Laura Flores, Crystal Krause, Sarah Samreen, Tiffany Tanner

Research output: Contribution to journalReview article

Abstract

Obesity is a worldwide epidemic with rates nearly doubling over the last 30 years. Despite increasing prevalence, the multifactorial pathogenesis of obesity continues to be widely misunderstood. Investigating genetic drivers in the development of obesity is an important area of focus, as genetics move to the forefront of medicine and personalized treatment evolves. Thus, this narrative review focused on four genes which have genome-wide association study–documented links to obesity and obesity syndromes. We explored their involvement in the predisposition, progression, and prognosis of obesity. Leptin, leptin receptor, pro-opiomelanocortin, and melanocortin 4 receptor are our four genes of interest, and herein we elaborated on the current literature, pathogenesis, and available treatments for patients with these specific genetic mutations.

Original languageEnglish (US)
Pages (from-to)4077-4083
Number of pages7
JournalObesity Surgery
Volume29
Issue number12
DOIs
StatePublished - Dec 1 2019
Externally publishedYes

Fingerprint

Obesity
Receptor, Melanocortin, Type 4
Leptin Receptors
Pro-Opiomelanocortin
Precision Medicine
Leptin
Genes
Genome
Mutation
Therapeutics

Keywords

  • Gene mutations
  • Genetics
  • Monogenic obesity
  • Obesity

ASJC Scopus subject areas

  • Surgery
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Baxter, J., Armijo, P. R., Flores, L., Krause, C., Samreen, S., & Tanner, T. (2019). Updates on Monogenic Obesity in a Multifactorial Disease. Obesity Surgery, 29(12), 4077-4083. https://doi.org/10.1007/s11695-019-04200-z

Updates on Monogenic Obesity in a Multifactorial Disease. / Baxter, Jared; Armijo, Priscila Rodrigues; Flores, Laura; Krause, Crystal; Samreen, Sarah; Tanner, Tiffany.

In: Obesity Surgery, Vol. 29, No. 12, 01.12.2019, p. 4077-4083.

Research output: Contribution to journalReview article

Baxter, J, Armijo, PR, Flores, L, Krause, C, Samreen, S & Tanner, T 2019, 'Updates on Monogenic Obesity in a Multifactorial Disease', Obesity Surgery, vol. 29, no. 12, pp. 4077-4083. https://doi.org/10.1007/s11695-019-04200-z
Baxter J, Armijo PR, Flores L, Krause C, Samreen S, Tanner T. Updates on Monogenic Obesity in a Multifactorial Disease. Obesity Surgery. 2019 Dec 1;29(12):4077-4083. https://doi.org/10.1007/s11695-019-04200-z
Baxter, Jared ; Armijo, Priscila Rodrigues ; Flores, Laura ; Krause, Crystal ; Samreen, Sarah ; Tanner, Tiffany. / Updates on Monogenic Obesity in a Multifactorial Disease. In: Obesity Surgery. 2019 ; Vol. 29, No. 12. pp. 4077-4083.
@article{cfbfc37e5246413fa2345a22cc392147,
title = "Updates on Monogenic Obesity in a Multifactorial Disease",
abstract = "Obesity is a worldwide epidemic with rates nearly doubling over the last 30 years. Despite increasing prevalence, the multifactorial pathogenesis of obesity continues to be widely misunderstood. Investigating genetic drivers in the development of obesity is an important area of focus, as genetics move to the forefront of medicine and personalized treatment evolves. Thus, this narrative review focused on four genes which have genome-wide association study–documented links to obesity and obesity syndromes. We explored their involvement in the predisposition, progression, and prognosis of obesity. Leptin, leptin receptor, pro-opiomelanocortin, and melanocortin 4 receptor are our four genes of interest, and herein we elaborated on the current literature, pathogenesis, and available treatments for patients with these specific genetic mutations.",
keywords = "Gene mutations, Genetics, Monogenic obesity, Obesity",
author = "Jared Baxter and Armijo, {Priscila Rodrigues} and Laura Flores and Crystal Krause and Sarah Samreen and Tiffany Tanner",
year = "2019",
month = "12",
day = "1",
doi = "10.1007/s11695-019-04200-z",
language = "English (US)",
volume = "29",
pages = "4077--4083",
journal = "Obesity Surgery",
issn = "0960-8923",
publisher = "Springer New York",
number = "12",

}

TY - JOUR

T1 - Updates on Monogenic Obesity in a Multifactorial Disease

AU - Baxter, Jared

AU - Armijo, Priscila Rodrigues

AU - Flores, Laura

AU - Krause, Crystal

AU - Samreen, Sarah

AU - Tanner, Tiffany

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Obesity is a worldwide epidemic with rates nearly doubling over the last 30 years. Despite increasing prevalence, the multifactorial pathogenesis of obesity continues to be widely misunderstood. Investigating genetic drivers in the development of obesity is an important area of focus, as genetics move to the forefront of medicine and personalized treatment evolves. Thus, this narrative review focused on four genes which have genome-wide association study–documented links to obesity and obesity syndromes. We explored their involvement in the predisposition, progression, and prognosis of obesity. Leptin, leptin receptor, pro-opiomelanocortin, and melanocortin 4 receptor are our four genes of interest, and herein we elaborated on the current literature, pathogenesis, and available treatments for patients with these specific genetic mutations.

AB - Obesity is a worldwide epidemic with rates nearly doubling over the last 30 years. Despite increasing prevalence, the multifactorial pathogenesis of obesity continues to be widely misunderstood. Investigating genetic drivers in the development of obesity is an important area of focus, as genetics move to the forefront of medicine and personalized treatment evolves. Thus, this narrative review focused on four genes which have genome-wide association study–documented links to obesity and obesity syndromes. We explored their involvement in the predisposition, progression, and prognosis of obesity. Leptin, leptin receptor, pro-opiomelanocortin, and melanocortin 4 receptor are our four genes of interest, and herein we elaborated on the current literature, pathogenesis, and available treatments for patients with these specific genetic mutations.

KW - Gene mutations

KW - Genetics

KW - Monogenic obesity

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=85074474294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074474294&partnerID=8YFLogxK

U2 - 10.1007/s11695-019-04200-z

DO - 10.1007/s11695-019-04200-z

M3 - Review article

C2 - 31641982

AN - SCOPUS:85074474294

VL - 29

SP - 4077

EP - 4083

JO - Obesity Surgery

JF - Obesity Surgery

SN - 0960-8923

IS - 12

ER -