Upolu virus and Aransas Bay virus, two presumptive bunyaviruses, are novel members of the family Orthomyxoviridae

Thomas Briese, Rashmi Chowdhary, Amelia Travassos Da Rosa, Stephen K. Hutchison, Vsevolod Popov, Craig Street, Robert B. Tesh, W. Ian Lipkin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Emerging and zoonotic pathogens pose continuing threats to human health and ongoing challenges to diagnostics. As nucleic acid tests are playing increasingly prominent roles in diagnostics, the genetic characterization of molecularly uncharacterized agents is expected to significantly enhance detection and surveillance capabilities. We report the identification of two previously unrecognized members of the family Orthomyxoviridae, which includes the influenza viruses and the tick-transmitted Thogoto and Dhori viruses. We provide morphological, serologic, and genetic evidence that Upolu virus (UPOV) from Australia and Aransas Bay virus (ABV) from North America, both previously considered potential bunyaviruses based on electron microscopy and physicochemical features, are orthomyxoviruses instead. Their genomes show up to 68% nucleotide sequence identity to Thogoto virus (segment 2;̃74% at the amino acid level) and a more distant relationship to Dhori virus, the two prototype viruses of the recognized species of the genus Thogotovirus. Despite sequence similarity, the coding potentials of UPOV and ABV differed from that of Thogoto virus, instead being like that of Dhori virus. Our findings suggest that the tick-transmitted viruses UPOV and ABV represent geographically distinct viruses in the genus Thogotovirus of the family Orthomyxoviridae that do not fit in the two currently recognized species of this genus.

Original languageEnglish (US)
Pages (from-to)5298-5309
Number of pages12
JournalJournal of Virology
Volume88
Issue number10
DOIs
StatePublished - 2014

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Thogotovirus
Orthobunyavirus
Orthomyxoviridae
Viruses
Dhori virus
viruses
Thogoto virus
Ticks
ticks
Zoonoses
North America
prototypes
Nucleic Acids
nucleic acids
human health
electron microscopy
Electron Microscopy
Genome

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Briese, T., Chowdhary, R., Da Rosa, A. T., Hutchison, S. K., Popov, V., Street, C., ... Lipkin, W. I. (2014). Upolu virus and Aransas Bay virus, two presumptive bunyaviruses, are novel members of the family Orthomyxoviridae. Journal of Virology, 88(10), 5298-5309. https://doi.org/10.1128/JVI.03391-13

Upolu virus and Aransas Bay virus, two presumptive bunyaviruses, are novel members of the family Orthomyxoviridae. / Briese, Thomas; Chowdhary, Rashmi; Da Rosa, Amelia Travassos; Hutchison, Stephen K.; Popov, Vsevolod; Street, Craig; Tesh, Robert B.; Lipkin, W. Ian.

In: Journal of Virology, Vol. 88, No. 10, 2014, p. 5298-5309.

Research output: Contribution to journalArticle

Briese, T, Chowdhary, R, Da Rosa, AT, Hutchison, SK, Popov, V, Street, C, Tesh, RB & Lipkin, WI 2014, 'Upolu virus and Aransas Bay virus, two presumptive bunyaviruses, are novel members of the family Orthomyxoviridae', Journal of Virology, vol. 88, no. 10, pp. 5298-5309. https://doi.org/10.1128/JVI.03391-13
Briese, Thomas ; Chowdhary, Rashmi ; Da Rosa, Amelia Travassos ; Hutchison, Stephen K. ; Popov, Vsevolod ; Street, Craig ; Tesh, Robert B. ; Lipkin, W. Ian. / Upolu virus and Aransas Bay virus, two presumptive bunyaviruses, are novel members of the family Orthomyxoviridae. In: Journal of Virology. 2014 ; Vol. 88, No. 10. pp. 5298-5309.
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