Ureteral axon damage following subcutaneous administration of capsaicin in adult rats

Kyungsoon Chung, Richard J. Schwen, Richarde E. Coggeshall

    Research output: Contribution to journalArticlepeer-review

    42 Scopus citations

    Abstract

    Systemic administration of capsaicin to adult rats results in the death of almost 90% of the axons in the ureter. Because of the massive axon loss we presume that sensory and possibly some sympathetic axons are killed. By contrast sensory axons in the dorsal root do not seem to be affected. We speculate that the axons in the ureter die because they are not protected by sleeves of perineurium. This hypothesis will be tested in subsequent work.

    Original languageEnglish (US)
    Pages (from-to)221-226
    Number of pages6
    JournalNeuroscience Letters
    Volume53
    Issue number2
    DOIs
    StatePublished - Jan 21 1985

    Keywords

    • capsaicin
    • rat
    • unmyelinated axons
    • ureter

    ASJC Scopus subject areas

    • General Neuroscience

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