Ureteral axon damage following subcutaneous administration of capsaicin in adult rats

Kyungsoon Chung; Richard J. Schwen; Richarde E. Coggeshall

doi:10.1016/0304-3940(85)90189-2

Ureteral axon damage following subcutaneous administration of capsaicin in adult rats

Kyungsoon Chung, Richard J. Schwen, Richarde E. Coggeshall

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42 Scopus citations

Abstract

Systemic administration of capsaicin to adult rats results in the death of almost 90% of the axons in the ureter. Because of the massive axon loss we presume that sensory and possibly some sympathetic axons are killed. By contrast sensory axons in the dorsal root do not seem to be affected. We speculate that the axons in the ureter die because they are not protected by sleeves of perineurium. This hypothesis will be tested in subsequent work.

Original language	English (US)
Pages (from-to)	221-226
Number of pages	6
Journal	Neuroscience Letters
Volume	53
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(85)90189-2
State	Published - Jan 21 1985
Externally published	Yes

Keywords

capsaicin
rat
unmyelinated axons
ureter

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(85)90189-2

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abstract = "Systemic administration of capsaicin to adult rats results in the death of almost 90% of the axons in the ureter. Because of the massive axon loss we presume that sensory and possibly some sympathetic axons are killed. By contrast sensory axons in the dorsal root do not seem to be affected. We speculate that the axons in the ureter die because they are not protected by sleeves of perineurium. This hypothesis will be tested in subsequent work.",

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AU - Schwen, Richard J.

AU - Coggeshall, Richarde E.

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Y1 - 1985/1/21

N2 - Systemic administration of capsaicin to adult rats results in the death of almost 90% of the axons in the ureter. Because of the massive axon loss we presume that sensory and possibly some sympathetic axons are killed. By contrast sensory axons in the dorsal root do not seem to be affected. We speculate that the axons in the ureter die because they are not protected by sleeves of perineurium. This hypothesis will be tested in subsequent work.

AB - Systemic administration of capsaicin to adult rats results in the death of almost 90% of the axons in the ureter. Because of the massive axon loss we presume that sensory and possibly some sympathetic axons are killed. By contrast sensory axons in the dorsal root do not seem to be affected. We speculate that the axons in the ureter die because they are not protected by sleeves of perineurium. This hypothesis will be tested in subsequent work.

KW - capsaicin

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KW - unmyelinated axons

KW - ureter

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Ureteral axon damage following subcutaneous administration of capsaicin in adult rats

Abstract

Keywords

ASJC Scopus subject areas

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