Urinary free 19-nor-deoxycorticosterone and deoxycorticosterone in human hypertension

C. E. Gomez-Sanchez, O. B. Holland, R. Upcavage

Research output: Contribution to journalArticle

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Abstract

The urinary excretion of deoxycorticosterone (DOC) and 19-nor-deoxycorticosterone (19-nor-DOC) was measured using a technique which consisted of the purification of both steroids by high pressure liquid chromatography followed by RIA using specific antibodies. The urinary excretion of DOC was 29.4 ± 25 ng/24 h (mean ± SD) in 35 normal subjects, 26 ± 21 ng/24 h in 46 patients with low renin hypertension (LRHT), and 32 ± 23 ng/24 in 16 patients with normal renin hypertension (NRHT). The urinary excretion of 19-nor-DOC was 287 ± 178 ng/24 h in normal subjects, 224 ± 167 ng/24 h in LRHT patients, and 235 ± 170 ng/24 h in NRHT patients. There were no hypertensive patients with increased excretion of 19-nor-DOC. The excretion of 19-nor-DOC increased after 3 days of sodium depletion in normal and hypertensive subjects, but the increment was significantly higher in normotensive subjects. There was no correlation between the excretion of 19-nor-DOC and that of DOC or urinary aldosterone. This study suggests that DOC or 19-nor-DOC does not play a role in the pathogenesis of either LRHT or NRHT and disagrees with previous reports suggesting such a role.

Original languageEnglish (US)
Pages (from-to)234-238
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume60
Issue number2
StatePublished - 1985

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Desoxycorticosterone
Hypertension
Renin
High pressure liquid chromatography
Aldosterone
Purification
Sodium
Steroids
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Urinary free 19-nor-deoxycorticosterone and deoxycorticosterone in human hypertension. / Gomez-Sanchez, C. E.; Holland, O. B.; Upcavage, R.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 60, No. 2, 1985, p. 234-238.

Research output: Contribution to journalArticle

Gomez-Sanchez, C. E. ; Holland, O. B. ; Upcavage, R. / Urinary free 19-nor-deoxycorticosterone and deoxycorticosterone in human hypertension. In: Journal of Clinical Endocrinology and Metabolism. 1985 ; Vol. 60, No. 2. pp. 234-238.
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