Urinary tetrahydroaldosterone and aldosterone-18-glucuronide excretion in white and black normal subjects and hypertensive patients

C. E. Gomez-Sanchez, O. B. Holland

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Urinary aldosterone excretion is commonly determined by assay of aldosterone liberated from the acid-labile metabolite, aldosterone-18-glucuronide (Aldo-18-G), which reflects 5-15% of aldosterone secretion. However, since 3α,5β-tetrahydroaldosterone (TH-Aldo), the major metabolite, reflects 15-40% of aldosterone excretion, determination of its excretion should usually provide a more accurate index of aldosterone secretion. We have validated a RIA for urinary TH-Aldo and compared its excretion in black and white normal subjects and patients with essential hypertension and primary aldosteronism during consumption of low, normal, and high sodium diets. Urinary TH-Aldo excretion averaged 4.5 ± 2.0 (mean ± SD) times that of Aldo-18-G. The ratio of excretion of the two remained relatively constant during low, normal, and high sodium diets. There was no difference in the excretion of TH-Aldo or Aldo-18-G in black vs. white normal subjects or hypertensive patients and no age-related changes in the excretion of either metabolite from 20-60 yr of age. Two of nine patients with primary aldosteronism had normal Aldo excretion. We conclude that determination of both metabolites increases the diagnostic accuracy for primary aldosteronism.

Original languageEnglish (US)
Pages (from-to)214-219
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume52
Issue number2
StatePublished - 1981

Fingerprint

Aldosterone
Metabolites
Hyperaldosteronism
Nutrition
Sodium
Diet
Assays
aldosterone 18-glucuronide
tetrahydroaldosterone
hydroquinone
Acids

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Urinary tetrahydroaldosterone and aldosterone-18-glucuronide excretion in white and black normal subjects and hypertensive patients. / Gomez-Sanchez, C. E.; Holland, O. B.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 52, No. 2, 1981, p. 214-219.

Research output: Contribution to journalArticle

@article{806f75a6efe6437e8c59f3698de67e1b,
title = "Urinary tetrahydroaldosterone and aldosterone-18-glucuronide excretion in white and black normal subjects and hypertensive patients",
abstract = "Urinary aldosterone excretion is commonly determined by assay of aldosterone liberated from the acid-labile metabolite, aldosterone-18-glucuronide (Aldo-18-G), which reflects 5-15{\%} of aldosterone secretion. However, since 3α,5β-tetrahydroaldosterone (TH-Aldo), the major metabolite, reflects 15-40{\%} of aldosterone excretion, determination of its excretion should usually provide a more accurate index of aldosterone secretion. We have validated a RIA for urinary TH-Aldo and compared its excretion in black and white normal subjects and patients with essential hypertension and primary aldosteronism during consumption of low, normal, and high sodium diets. Urinary TH-Aldo excretion averaged 4.5 ± 2.0 (mean ± SD) times that of Aldo-18-G. The ratio of excretion of the two remained relatively constant during low, normal, and high sodium diets. There was no difference in the excretion of TH-Aldo or Aldo-18-G in black vs. white normal subjects or hypertensive patients and no age-related changes in the excretion of either metabolite from 20-60 yr of age. Two of nine patients with primary aldosteronism had normal Aldo excretion. We conclude that determination of both metabolites increases the diagnostic accuracy for primary aldosteronism.",
author = "Gomez-Sanchez, {C. E.} and Holland, {O. B.}",
year = "1981",
language = "English (US)",
volume = "52",
pages = "214--219",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "2",

}

TY - JOUR

T1 - Urinary tetrahydroaldosterone and aldosterone-18-glucuronide excretion in white and black normal subjects and hypertensive patients

AU - Gomez-Sanchez, C. E.

AU - Holland, O. B.

PY - 1981

Y1 - 1981

N2 - Urinary aldosterone excretion is commonly determined by assay of aldosterone liberated from the acid-labile metabolite, aldosterone-18-glucuronide (Aldo-18-G), which reflects 5-15% of aldosterone secretion. However, since 3α,5β-tetrahydroaldosterone (TH-Aldo), the major metabolite, reflects 15-40% of aldosterone excretion, determination of its excretion should usually provide a more accurate index of aldosterone secretion. We have validated a RIA for urinary TH-Aldo and compared its excretion in black and white normal subjects and patients with essential hypertension and primary aldosteronism during consumption of low, normal, and high sodium diets. Urinary TH-Aldo excretion averaged 4.5 ± 2.0 (mean ± SD) times that of Aldo-18-G. The ratio of excretion of the two remained relatively constant during low, normal, and high sodium diets. There was no difference in the excretion of TH-Aldo or Aldo-18-G in black vs. white normal subjects or hypertensive patients and no age-related changes in the excretion of either metabolite from 20-60 yr of age. Two of nine patients with primary aldosteronism had normal Aldo excretion. We conclude that determination of both metabolites increases the diagnostic accuracy for primary aldosteronism.

AB - Urinary aldosterone excretion is commonly determined by assay of aldosterone liberated from the acid-labile metabolite, aldosterone-18-glucuronide (Aldo-18-G), which reflects 5-15% of aldosterone secretion. However, since 3α,5β-tetrahydroaldosterone (TH-Aldo), the major metabolite, reflects 15-40% of aldosterone excretion, determination of its excretion should usually provide a more accurate index of aldosterone secretion. We have validated a RIA for urinary TH-Aldo and compared its excretion in black and white normal subjects and patients with essential hypertension and primary aldosteronism during consumption of low, normal, and high sodium diets. Urinary TH-Aldo excretion averaged 4.5 ± 2.0 (mean ± SD) times that of Aldo-18-G. The ratio of excretion of the two remained relatively constant during low, normal, and high sodium diets. There was no difference in the excretion of TH-Aldo or Aldo-18-G in black vs. white normal subjects or hypertensive patients and no age-related changes in the excretion of either metabolite from 20-60 yr of age. Two of nine patients with primary aldosteronism had normal Aldo excretion. We conclude that determination of both metabolites increases the diagnostic accuracy for primary aldosteronism.

UR - http://www.scopus.com/inward/record.url?scp=0019367102&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019367102&partnerID=8YFLogxK

M3 - Article

C2 - 7462387

AN - SCOPUS:0019367102

VL - 52

SP - 214

EP - 219

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 2

ER -