Urinary tetrahydroaldosterone and aldosterone-18-glucuronide excretion in white and black normal subjects and hypertensive patients

C. E. Gomez-Sanchez, O. B. Holland

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Urinary aldosterone excretion is commonly determined by assay of aldosterone liberated from the acid-labile metabolite, aldosterone-18-glucuronide (Aldo-18-G), which reflects 5-15% of aldosterone secretion. However, since 3α,5β-tetrahydroaldosterone (TH-Aldo), the major metabolite, reflects 15-40% of aldosterone excretion, determination of its excretion should usually provide a more accurate index of aldosterone secretion. We have validated a RIA for urinary TH-Aldo and compared its excretion in black and white normal subjects and patients with essential hypertension and primary aldosteronism during consumption of low, normal, and high sodium diets. Urinary TH-Aldo excretion averaged 4.5 ± 2.0 (mean ± SD) times that of Aldo-18-G. The ratio of excretion of the two remained relatively constant during low, normal, and high sodium diets. There was no difference in the excretion of TH-Aldo or Aldo-18-G in black vs. white normal subjects or hypertensive patients and no age-related changes in the excretion of either metabolite from 20-60 yr of age. Two of nine patients with primary aldosteronism had normal Aldo excretion. We conclude that determination of both metabolites increases the diagnostic accuracy for primary aldosteronism.

Original languageEnglish (US)
Pages (from-to)214-219
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume52
Issue number2
StatePublished - 1981

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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