Urothelial hyperplasia and neoplasia: A response to chronic urinary tract infections in rats

C. P. Davis, M. S. Cohen, M. B. Gruber, M. D. Anderson, M. M. Warren

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The rat was used as an animal model to examine the effect of foreign bodies and long term infection (24 weeks) on bladder epithelium. Stainless steel wire implants and multiple injections of Escherichia coli were compared to control rat bladders by gross observation, light microscopy and scanning electron microscopy. Hyperplastic alterations, (papilloma, von Brunn's nests), dysplasia (squamous metaplasia, microvilli) and early lesions consistent with neoplasia occurred in rats with bladder implants and multiple bacterial injections but not in controls. Epithelial changes were not associated with sterile bladder implants. Bladder papillomata could be observed as early as 2 weeks in rats having both an implant and an infection, but the majority of hyperplastic and early neoplastic-like changes occurred after 6 weeks. Long-term infections, both with and without a bladder implant, can lead to lesions consistent with neoplasia in bladder epithelium.

Original languageEnglish (US)
Pages (from-to)1025-1031
Number of pages7
JournalJournal of Urology
Volume132
Issue number5
StatePublished - 1984

Fingerprint

Urinary Tract Infections
Hyperplasia
Urinary Bladder
Neoplasms
Papilloma
Epithelium
Infection
Injections
Stainless Steel
Metaplasia
Microvilli
Foreign Bodies
Electron Scanning Microscopy
Microscopy
Animal Models
Observation
Escherichia coli
Light

ASJC Scopus subject areas

  • Urology

Cite this

Davis, C. P., Cohen, M. S., Gruber, M. B., Anderson, M. D., & Warren, M. M. (1984). Urothelial hyperplasia and neoplasia: A response to chronic urinary tract infections in rats. Journal of Urology, 132(5), 1025-1031.

Urothelial hyperplasia and neoplasia : A response to chronic urinary tract infections in rats. / Davis, C. P.; Cohen, M. S.; Gruber, M. B.; Anderson, M. D.; Warren, M. M.

In: Journal of Urology, Vol. 132, No. 5, 1984, p. 1025-1031.

Research output: Contribution to journalArticle

Davis, CP, Cohen, MS, Gruber, MB, Anderson, MD & Warren, MM 1984, 'Urothelial hyperplasia and neoplasia: A response to chronic urinary tract infections in rats', Journal of Urology, vol. 132, no. 5, pp. 1025-1031.
Davis CP, Cohen MS, Gruber MB, Anderson MD, Warren MM. Urothelial hyperplasia and neoplasia: A response to chronic urinary tract infections in rats. Journal of Urology. 1984;132(5):1025-1031.
Davis, C. P. ; Cohen, M. S. ; Gruber, M. B. ; Anderson, M. D. ; Warren, M. M. / Urothelial hyperplasia and neoplasia : A response to chronic urinary tract infections in rats. In: Journal of Urology. 1984 ; Vol. 132, No. 5. pp. 1025-1031.
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