Urothelial hyperplasia and neoplasia: A response to chronic urinary tract infections in rats

C. P. Davis, M. S. Cohen, M. B. Gruber, M. D. Anderson, M. M. Warren

    Research output: Contribution to journalArticle

    42 Scopus citations

    Abstract

    The rat was used as an animal model to examine the effect of foreign bodies and long term infection (24 weeks) on bladder epithelium. Stainless steel wire implants and multiple injections of Escherichia coli were compared to control rat bladders by gross observation, light microscopy and scanning electron microscopy. Hyperplastic alterations, (papilloma, von Brunn's nests), dysplasia (squamous metaplasia, microvilli) and early lesions consistent with neoplasia occurred in rats with bladder implants and multiple bacterial injections but not in controls. Epithelial changes were not associated with sterile bladder implants. Bladder papillomata could be observed as early as 2 weeks in rats having both an implant and an infection, but the majority of hyperplastic and early neoplastic-like changes occurred after 6 weeks. Long-term infections, both with and without a bladder implant, can lead to lesions consistent with neoplasia in bladder epithelium.

    Original languageEnglish (US)
    Pages (from-to)1025-1031
    Number of pages7
    JournalJournal of Urology
    Volume132
    Issue number5
    DOIs
    StatePublished - Jan 1 1984

    ASJC Scopus subject areas

    • Urology

    Fingerprint Dive into the research topics of 'Urothelial hyperplasia and neoplasia: A response to chronic urinary tract infections in rats'. Together they form a unique fingerprint.

  • Cite this

    Davis, C. P., Cohen, M. S., Gruber, M. B., Anderson, M. D., & Warren, M. M. (1984). Urothelial hyperplasia and neoplasia: A response to chronic urinary tract infections in rats. Journal of Urology, 132(5), 1025-1031. https://doi.org/10.1016/S0022-5347(17)49992-7