Use of Abciximab During Infrainguinal Peripheral Vascular Interventions: Initial Experience

Michael B. Silva, W. Todd Bohannon

Research output: Contribution to journalArticlepeer-review


The use of abciximab in conjunction with infrainguinal angioplasty in 16 patients over an 18-month period in 1999 was investigated. Abciximab was given to patients thought to be at high risk for a thrombotic or embolic complication. Ten patients had high-grade stenoses or occlusions in the popliteal artery and superficial femoral artery; six patients had stenoses or occlusions below the popliteal artery. After arterial access was achieved, all patients received a bolus of heparin. A weight-based nomogram, consisting of an initial bolus followed by an overnight infusion, was used to administer the abciximab. A less than 30% residual stenosis after angioplasty was considered a technical success. Patients were monitored for complications following the procedure and platelet counts were monitored for 24 hours. Technical success occurred in 94% (15116) of the patients. No significant effect on platelet count was noted. Two minor complications occurred. The major complication was a groin hematoma in a patient who was also undergoing chronic antiplatelet therapy with aspirin and clopidogrel. Abciximab has promise as an adjunct during complex infrainguinal arterial interventions but further study is needed.

Original languageEnglish (US)
Pages (from-to)153-154
Number of pages2
JournalPerspectives in Vascular Surgery and Endovascular Therapy
Issue number2
StatePublished - Jun 2004
Externally publishedYes


  • infrainguinal angioplasty
  • popliteal artery
  • stenosis
  • superficial femoral artery

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine


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