Use of prophylactic anticonvulsants in neurologic critical care: A critical appraisal

Kenneth C. Liu; Anish Bhardwaj

doi:10.1007/s12028-007-0061-5

Use of prophylactic anticonvulsants in neurologic critical care: A critical appraisal

Kenneth C. Liu, Anish Bhardwaj

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Seizures are commonly encountered in the setting of brain injury in neurologic critical care. Though seizure prophylaxis with the use of antiepileptic drugs is frequently utilized in variety of brain injury paradigms, it is often not based on evidence and is controversial. Significant difficulties arise from interpretation of supporting literature due to lack of definitions for early-vs.-late-seizures, variable end points with seizure prophylaxis, as well as methodologic inconsistencies for seizure detection. This descriptive review summarizes the existing literature on the use of prophylactic anticonvulsants in clinical paradigms commonly encountered in neurologic critical care and highlights the important controversies concerning their use.

Original language	English (US)
Pages (from-to)	175-184
Number of pages	10
Journal	Neurocritical Care
Volume	7
Issue number	2
DOIs	https://doi.org/10.1007/s12028-007-0061-5
State	Published - Oct 2007
Externally published	Yes

Keywords

Anticonvulsants
Epilepsy
Neurologic critical care
Seizures

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine
Clinical Neurology

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10.1007/s12028-007-0061-5

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title = "Use of prophylactic anticonvulsants in neurologic critical care: A critical appraisal",

abstract = "Seizures are commonly encountered in the setting of brain injury in neurologic critical care. Though seizure prophylaxis with the use of antiepileptic drugs is frequently utilized in variety of brain injury paradigms, it is often not based on evidence and is controversial. Significant difficulties arise from interpretation of supporting literature due to lack of definitions for early-vs.-late-seizures, variable end points with seizure prophylaxis, as well as methodologic inconsistencies for seizure detection. This descriptive review summarizes the existing literature on the use of prophylactic anticonvulsants in clinical paradigms commonly encountered in neurologic critical care and highlights the important controversies concerning their use.",

keywords = "Anticonvulsants, Epilepsy, Neurologic critical care, Seizures",

author = "Liu, {Kenneth C.} and Anish Bhardwaj",

note = "Funding Information: Acknowledgments Source of Support: This work was supported by Public Health Service NIH grant NS046379. The authors thank Tzi-pora Sofare, MA, for her editorial assistance in preparing this manuscript.",

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AU - Liu, Kenneth C.

AU - Bhardwaj, Anish

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AB - Seizures are commonly encountered in the setting of brain injury in neurologic critical care. Though seizure prophylaxis with the use of antiepileptic drugs is frequently utilized in variety of brain injury paradigms, it is often not based on evidence and is controversial. Significant difficulties arise from interpretation of supporting literature due to lack of definitions for early-vs.-late-seizures, variable end points with seizure prophylaxis, as well as methodologic inconsistencies for seizure detection. This descriptive review summarizes the existing literature on the use of prophylactic anticonvulsants in clinical paradigms commonly encountered in neurologic critical care and highlights the important controversies concerning their use.

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Use of prophylactic anticonvulsants in neurologic critical care: A critical appraisal

Abstract

Keywords

ASJC Scopus subject areas

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