Abstract
Seizures are commonly encountered in the setting of brain injury in neurologic critical care. Though seizure prophylaxis with the use of antiepileptic drugs is frequently utilized in variety of brain injury paradigms, it is often not based on evidence and is controversial. Significant difficulties arise from interpretation of supporting literature due to lack of definitions for early-vs.-late-seizures, variable end points with seizure prophylaxis, as well as methodologic inconsistencies for seizure detection. This descriptive review summarizes the existing literature on the use of prophylactic anticonvulsants in clinical paradigms commonly encountered in neurologic critical care and highlights the important controversies concerning their use.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 175-184 |
| Number of pages | 10 |
| Journal | Neurocritical Care |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 2007 |
| Externally published | Yes |
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Keywords
- Anticonvulsants
- Epilepsy
- Neurologic critical care
- Seizures
ASJC Scopus subject areas
- Clinical Neurology
- Critical Care and Intensive Care Medicine
Cite this
Use of prophylactic anticonvulsants in neurologic critical care : A critical appraisal. / Liu, Kenneth C.; Bhardwaj, Anish.
In: Neurocritical Care, Vol. 7, No. 2, 10.2007, p. 175-184.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Use of prophylactic anticonvulsants in neurologic critical care
T2 - A critical appraisal
AU - Liu, Kenneth C.
AU - Bhardwaj, Anish
PY - 2007/10
Y1 - 2007/10
N2 - Seizures are commonly encountered in the setting of brain injury in neurologic critical care. Though seizure prophylaxis with the use of antiepileptic drugs is frequently utilized in variety of brain injury paradigms, it is often not based on evidence and is controversial. Significant difficulties arise from interpretation of supporting literature due to lack of definitions for early-vs.-late-seizures, variable end points with seizure prophylaxis, as well as methodologic inconsistencies for seizure detection. This descriptive review summarizes the existing literature on the use of prophylactic anticonvulsants in clinical paradigms commonly encountered in neurologic critical care and highlights the important controversies concerning their use.
AB - Seizures are commonly encountered in the setting of brain injury in neurologic critical care. Though seizure prophylaxis with the use of antiepileptic drugs is frequently utilized in variety of brain injury paradigms, it is often not based on evidence and is controversial. Significant difficulties arise from interpretation of supporting literature due to lack of definitions for early-vs.-late-seizures, variable end points with seizure prophylaxis, as well as methodologic inconsistencies for seizure detection. This descriptive review summarizes the existing literature on the use of prophylactic anticonvulsants in clinical paradigms commonly encountered in neurologic critical care and highlights the important controversies concerning their use.
KW - Anticonvulsants
KW - Epilepsy
KW - Neurologic critical care
KW - Seizures
UR - http://www.scopus.com/inward/record.url?scp=36949009452&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36949009452&partnerID=8YFLogxK
U2 - 10.1007/s12028-007-0061-5
DO - 10.1007/s12028-007-0061-5
M3 - Article
VL - 7
SP - 175
EP - 184
JO - Neurocritical Care
JF - Neurocritical Care
SN - 1541-6933
IS - 2
ER -