Use of RNA interference to prevent lethal murine West Nile virus infection

Fengwei Bai, Tian Wang, Utpal Pal, Fukai Bao, L. Hannah Gould, Erol Fikrig

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

West Nile virus causes fatal encephalitis in humans, mice, and other vertebrates. In the present study, we demonstrate that small interfering RNAs (siRNAs) inhibit West Nile virus replication in vitro. Moreover, the administration of siRNAs to mice by hydrodynamic injection 24 h before challenge with an intraperitoneal inoculum of West Nile virus reduced the viral load and afforded partial protection from lethal infection. These data show the efficacy of the prophylactic use of siRNAs against a viral infection in vivo and suggest new strategies to combat West Nile virus.

Original languageEnglish (US)
Pages (from-to)1148-1154
Number of pages7
JournalJournal of Infectious Diseases
Volume191
Issue number7
DOIs
StatePublished - Apr 1 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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