@article{066fea1373414809a1dc9b31b1621a5c,
title = "Use of single-injection recombinant vesicular stomatitis virus vaccine to protect nonhuman primates against lethal nipah virus disease",
abstract = "Nipah virus (NiV) is a zoonotic pathogen that causes high case-fatality rates (CFRs) in humans. Two NiV strains have caused outbreaks: the Malaysia strain (NiVM), discovered in 1998-1999 in Malaysia and Singapore (≈40% CFR); and the Bangladesh strain (NiVB), discovered in Bangladesh and India in 2001 (≈80% CFR). Recently, NiVB in African green monkeys resulted in a more severe and lethal disease than NiVM. No NiV vaccines or treatments are licensed for human use. We assessed replication-restricted singleinjection recombinant vesicular stomatitis vaccine NiV vaccine vectors expressing the NiV glycoproteins against NiVB challenge in African green monkeys. All vaccinated animals survived to the study endpoint without signs of NiV disease; all showed development of NiV F Ig, NiV G IgG, or both, as well as neutralizing antibody titers. These data show protective efficacy against a stringent and relevant NiVB model of human infection.",
author = "Mire, {Chad E.} and Geisbert, {Joan B.} and Agans, {Krystle N.} and Versteeg, {Krista M.} and Deer, {Daniel J.} and Satterfield, {Benjamin A.} and Fenton, {Karla A.} and Geisbert, {Thomas W.}",
note = "Funding Information: This study was supported in part by National Institutes of Health (U01 AI082121 for research and UC7AI094660 for BSL-4 operations) and by funds provided to T.W.G. by the UTMB Funding Information: We thank the staff of the University of Texas Medical Branch Animal Resources Center for animal husbandry, Robert W. Cross for assistance with the animal study, and Natalie Dobias for assistance with histologic processing. We thank Thomas G. Ksiazek for kindly providing the NiVB isolate used in this study. This study was supported in part by National Institutes of Health (U01 AI082121 for research and UC7AI094660 for BSL-4 operations) and by funds provided to T.W.G. by the UTMB Department of Microbiology and Immunology. Publisher Copyright: {\textcopyright} 2019, Centers for Disease Control and Prevention (CDC). All rights reserved.",
year = "2019",
month = jun,
doi = "10.3201/eid2506.181620",
language = "English (US)",
volume = "25",
pages = "1144--1152",
journal = "Emerging Infectious Diseases",
issn = "1080-6040",
publisher = "Centers for Disease Control and Prevention (CDC)",
number = "6",
}