Use of touch preps for diagnosis and evaluation of surgical margins in breast cancer

Vicki Klimberg, Kent C. Westbrook, Soheila Korourian

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Background: The best cosmetic results with conservative breast surgery are obtained at the time of initial excisional biopsy. The usefulness of the touch prep (TP) technique was evaluated for accuracy in diagnosis as well as in evaluation of margins at the time of original breast biopsy. Methods: Four hundred twenty-eight consecutive patients with breast masses seen from January 1993 to December 1994 were evaluated prospectively using TP. Results: Three hundred forty-five benign and 83 malignant tumors were evaluated. Tumors ranged in size from microscopic to 8 cm. Pathologic diagnosis was correct as compared to permanent section in 99.3%. The three carcinomas missed on TP were focal and in situ. Sensitivity was 96.39%, and specificity was 100%. Positive predictive value was 100%, and negative predictive value was 99.3%. For margin evaluation, the sensitivity and specificity were both estimated to be 100%. Conclusions: TP has the advantage of being a simple, quick (2 to 3 minutes), safe (no loss of diagnostic material), and accurate method for diagnosis and estimation of tumor margins at the time of the original surgery.

Original languageEnglish (US)
Pages (from-to)220-226
Number of pages7
JournalAnnals of Surgical Oncology
Volume5
Issue number3
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

Touch
Breast Neoplasms
Breast
Biopsy
Neoplasms
Cosmetics
Carcinoma
Sensitivity and Specificity
Margins of Excision

Keywords

  • Breast cancer
  • Diagnosis
  • Margins
  • Touch prep-

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Use of touch preps for diagnosis and evaluation of surgical margins in breast cancer. / Klimberg, Vicki; Westbrook, Kent C.; Korourian, Soheila.

In: Annals of Surgical Oncology, Vol. 5, No. 3, 1998, p. 220-226.

Research output: Contribution to journalArticle

Klimberg, Vicki ; Westbrook, Kent C. ; Korourian, Soheila. / Use of touch preps for diagnosis and evaluation of surgical margins in breast cancer. In: Annals of Surgical Oncology. 1998 ; Vol. 5, No. 3. pp. 220-226.
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