Using reverse genetics to manipulate the NSs gene of the rift valley fever virus MP-12 strain to improve vaccine safety and efficacy

Medicine & Life Sciences

• Adaptive Immunity 8%
• Antiviral Agents 6%
• Blindness 8%
• Bunyaviridae 12%
• Dendritic Cells 7%
• Double-Stranded RNA 9%
• eIF-2 Kinase 22%
• Fever 6%
• Genes 22%
• Induced Abortion 9%
• Innate Immunity 14%
• Interferon alpha-beta Receptor 12%
• Interferon Regulatory Factor-3 23%
• Interferon Type I 28%
• Interferon-alpha 7%
• Interferon-beta 64%
• Interferons 14%
• Nervous System Diseases 7%
• NF-kappa B 17%
• Open Reading Frames 7%
• Phlebovirus 13%
• Protein Binding 7%
• Reverse Genetics 74%
• Rift Valley fever virus 87%
• RNA 5%
• RNA Stability 8%
• Ruminants 9%
• Safety 32%
• Transcription Factor AP-1 17%
• United States Department of Agriculture 11%
• Up-Regulation 5%
• Vaccination 6%
• Vaccines 42%
• Virulence Factors 8%

Engineering & Materials Science

• Dendritic Cells 6%
• Genes 53%
• Genetics 75%
• Interferons 100%
• Messenger RNA 10%
• Pathogens 10%
• Proteins 10%
• RNA 9%
• Transcription 13%
• Vaccines 76%
• Viruses 65%

Chemical Compounds

• Disorder 15%
• Mutation 15%
• Protein 7%
• Safety 47%
• Strain 38%
• Virulence Factor 25%