Abstract
Aim: We sought to determine if opioid exposure may have a detrimental effect on the course of Clostridioides difficile infection (CDI). Materials & methods: We compared opioid exposure in patients with well-defined severe CDI and non-severe CDI. Results: Following exclusions, 403 records were reviewed. Of this group, 128/403 (31.7%) were determined to have severe CDI by strict criteria, and 275/403 (68.3%) were found to have non-severe CDI. Full multivariate regression and reduced model of potential predictors for severe CDI showed no association with opioids prescribed. Conclusion: Opioid exposure (predominantly in modest range) does not appear to be a risk factor for severe healthcare-associated CDI.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 151-157 |
| Number of pages | 7 |
| Journal | Pain Management |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2021 |
| Externally published | Yes |
Keywords
- Clostridium difficile infection
- healthcare-associated infections
- nosocomial infections
- opioids
- pain management
- severe Clostridioides difficile infection
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
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