Uterine electromyography characteristics for early diagnosis of mifepristone-induced preterm labor

Muriel Doret, Radek Bukowski, Monica Longo, Holger Maul, William L. Maner, Robert E. Garfield, George Saade

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

OBJECTIVE: Differentiating uterine contractions leading to preterm birth from ineffective uterine activity is difficult with current tools. Uterine electromyographic activity is recordable and consists of bursts (group of action potentials) characterized by characteristics that are different during pregnancy and labor. Our aim was to identify the chronology of the changes in uterine pressure and electromyographic characteristics during mifepristone-induced preterm labor in pregnant rats and to determine the earliest characteristic to change. METHODS: On day 17 of gestation, intrauterine catheter and electromyography electrodes were implanted in the uterus. On day 18, rats were allocated for treatment with mifepristone or placebo. Intrauterine pressure and electromyography integral activities and electromyography mean were calculated before treatment and 6, 12, 18, 20, 22, and 24 hours after treatment. After mathematical transformation, burst analysis was performed by using power density spectrum energy, peak amplitude, and frequency. RESULTS: As expected, delivery rate within 24 hours was higher in the mifepristone-treated group. Changes in electromyography integral activity and mean, power density spectrum energy, and intrauterine pressure integral activity occurred late during preterm labor, in a range of 2-4 hours before delivery. Electromyography peak frequency of the power density spectrum exhibited early changes, with a shift from low to high frequencies starting at 12 hours before delivery. CONCLUSION: Electromyography peak frequency of the power density spectrum from individual bursts was the first characteristic to change after antiprogestin treatment, preceding any change in intrauterine pressure, making it a potentially useful marker for the early diagnosis of preterm labor.

Original languageEnglish (US)
Pages (from-to)822-830
Number of pages9
JournalObstetrics and Gynecology
Volume105
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Induced Labor
Mifepristone
Premature Obstetric Labor
Electromyography
Early Diagnosis
Pressure
Chronology
Uterine Contraction
Pregnancy
Implanted Electrodes
Premature Birth
Therapeutics
Action Potentials
Uterus
Catheters
Placebos

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Uterine electromyography characteristics for early diagnosis of mifepristone-induced preterm labor. / Doret, Muriel; Bukowski, Radek; Longo, Monica; Maul, Holger; Maner, William L.; Garfield, Robert E.; Saade, George.

In: Obstetrics and Gynecology, Vol. 105, No. 4, 04.2005, p. 822-830.

Research output: Contribution to journalArticle

Doret, Muriel ; Bukowski, Radek ; Longo, Monica ; Maul, Holger ; Maner, William L. ; Garfield, Robert E. ; Saade, George. / Uterine electromyography characteristics for early diagnosis of mifepristone-induced preterm labor. In: Obstetrics and Gynecology. 2005 ; Vol. 105, No. 4. pp. 822-830.
@article{2330a470e8af4f66be07c7c26ad5d67e,
title = "Uterine electromyography characteristics for early diagnosis of mifepristone-induced preterm labor",
abstract = "OBJECTIVE: Differentiating uterine contractions leading to preterm birth from ineffective uterine activity is difficult with current tools. Uterine electromyographic activity is recordable and consists of bursts (group of action potentials) characterized by characteristics that are different during pregnancy and labor. Our aim was to identify the chronology of the changes in uterine pressure and electromyographic characteristics during mifepristone-induced preterm labor in pregnant rats and to determine the earliest characteristic to change. METHODS: On day 17 of gestation, intrauterine catheter and electromyography electrodes were implanted in the uterus. On day 18, rats were allocated for treatment with mifepristone or placebo. Intrauterine pressure and electromyography integral activities and electromyography mean were calculated before treatment and 6, 12, 18, 20, 22, and 24 hours after treatment. After mathematical transformation, burst analysis was performed by using power density spectrum energy, peak amplitude, and frequency. RESULTS: As expected, delivery rate within 24 hours was higher in the mifepristone-treated group. Changes in electromyography integral activity and mean, power density spectrum energy, and intrauterine pressure integral activity occurred late during preterm labor, in a range of 2-4 hours before delivery. Electromyography peak frequency of the power density spectrum exhibited early changes, with a shift from low to high frequencies starting at 12 hours before delivery. CONCLUSION: Electromyography peak frequency of the power density spectrum from individual bursts was the first characteristic to change after antiprogestin treatment, preceding any change in intrauterine pressure, making it a potentially useful marker for the early diagnosis of preterm labor.",
author = "Muriel Doret and Radek Bukowski and Monica Longo and Holger Maul and Maner, {William L.} and Garfield, {Robert E.} and George Saade",
year = "2005",
month = "4",
doi = "10.1097/01.AOG.0000157110.62926.d7",
language = "English (US)",
volume = "105",
pages = "822--830",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Uterine electromyography characteristics for early diagnosis of mifepristone-induced preterm labor

AU - Doret, Muriel

AU - Bukowski, Radek

AU - Longo, Monica

AU - Maul, Holger

AU - Maner, William L.

AU - Garfield, Robert E.

AU - Saade, George

PY - 2005/4

Y1 - 2005/4

N2 - OBJECTIVE: Differentiating uterine contractions leading to preterm birth from ineffective uterine activity is difficult with current tools. Uterine electromyographic activity is recordable and consists of bursts (group of action potentials) characterized by characteristics that are different during pregnancy and labor. Our aim was to identify the chronology of the changes in uterine pressure and electromyographic characteristics during mifepristone-induced preterm labor in pregnant rats and to determine the earliest characteristic to change. METHODS: On day 17 of gestation, intrauterine catheter and electromyography electrodes were implanted in the uterus. On day 18, rats were allocated for treatment with mifepristone or placebo. Intrauterine pressure and electromyography integral activities and electromyography mean were calculated before treatment and 6, 12, 18, 20, 22, and 24 hours after treatment. After mathematical transformation, burst analysis was performed by using power density spectrum energy, peak amplitude, and frequency. RESULTS: As expected, delivery rate within 24 hours was higher in the mifepristone-treated group. Changes in electromyography integral activity and mean, power density spectrum energy, and intrauterine pressure integral activity occurred late during preterm labor, in a range of 2-4 hours before delivery. Electromyography peak frequency of the power density spectrum exhibited early changes, with a shift from low to high frequencies starting at 12 hours before delivery. CONCLUSION: Electromyography peak frequency of the power density spectrum from individual bursts was the first characteristic to change after antiprogestin treatment, preceding any change in intrauterine pressure, making it a potentially useful marker for the early diagnosis of preterm labor.

AB - OBJECTIVE: Differentiating uterine contractions leading to preterm birth from ineffective uterine activity is difficult with current tools. Uterine electromyographic activity is recordable and consists of bursts (group of action potentials) characterized by characteristics that are different during pregnancy and labor. Our aim was to identify the chronology of the changes in uterine pressure and electromyographic characteristics during mifepristone-induced preterm labor in pregnant rats and to determine the earliest characteristic to change. METHODS: On day 17 of gestation, intrauterine catheter and electromyography electrodes were implanted in the uterus. On day 18, rats were allocated for treatment with mifepristone or placebo. Intrauterine pressure and electromyography integral activities and electromyography mean were calculated before treatment and 6, 12, 18, 20, 22, and 24 hours after treatment. After mathematical transformation, burst analysis was performed by using power density spectrum energy, peak amplitude, and frequency. RESULTS: As expected, delivery rate within 24 hours was higher in the mifepristone-treated group. Changes in electromyography integral activity and mean, power density spectrum energy, and intrauterine pressure integral activity occurred late during preterm labor, in a range of 2-4 hours before delivery. Electromyography peak frequency of the power density spectrum exhibited early changes, with a shift from low to high frequencies starting at 12 hours before delivery. CONCLUSION: Electromyography peak frequency of the power density spectrum from individual bursts was the first characteristic to change after antiprogestin treatment, preceding any change in intrauterine pressure, making it a potentially useful marker for the early diagnosis of preterm labor.

UR - http://www.scopus.com/inward/record.url?scp=15944371347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15944371347&partnerID=8YFLogxK

U2 - 10.1097/01.AOG.0000157110.62926.d7

DO - 10.1097/01.AOG.0000157110.62926.d7

M3 - Article

VL - 105

SP - 822

EP - 830

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 4

ER -