Utility of intraoperative frozen section analysis of sentinel lymph nodes in breast cancer

Celia Chao, Sandra L. Wong, Douglas Ackermann, Diana Simpson, Mary B. Carter, C. Matthew Brown, Michael J. Edwards, Kelly M. McMasters

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Background: Intraoperative frozen section pathologic analysis of sentinel lymph node (SLN) may guide immediate (single-stage) completion axillary dissection for patients with nodal metastases. Methods: The results of 203 consecutive patients undergoing SLN biopsy who had intraoperative pathology consultation between January 1998 and September 2000 were reviewed. SLN were analyzed by standard frozen section procedures. Final pathologic analysis included hematoxylin and eosin (H&E) staining of serial sections at 2-mm intervals. Results: Frozen section analysis correctly identified a positive or negative result in 185 of 203 cases (overall accuracy 91%). In 17 of 53 cases, the SLNs were negative for tumor by frozen section, but positive on permanent section analysis (sensitivity 68%). The mean size of the nodal metastases was 6.2 mm and 1.5 mm in patients found to have true positive and false negative results, respectively (P <0.003). A single false positive SLN is reported. Conclusions: Two thirds of the patients were spared the need for reoperative axillary lymphadenectomy.

Original languageEnglish (US)
Pages (from-to)609-615
Number of pages7
JournalAmerican Journal of Surgery
Volume182
Issue number6
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Frozen Sections
Breast Neoplasms
Neoplasm Metastasis
Sentinel Lymph Node Biopsy
Hematoxylin
Eosine Yellowish-(YS)
Lymph Node Excision
Dissection
Referral and Consultation
Pathology
Staining and Labeling
Sentinel Lymph Node
Neoplasms

Keywords

  • Breast cancer
  • Frozen section
  • Sentinel lymph node

ASJC Scopus subject areas

  • Surgery

Cite this

Chao, C., Wong, S. L., Ackermann, D., Simpson, D., Carter, M. B., Brown, C. M., ... McMasters, K. M. (2001). Utility of intraoperative frozen section analysis of sentinel lymph nodes in breast cancer. American Journal of Surgery, 182(6), 609-615. https://doi.org/10.1016/S0002-9610(01)00794-2

Utility of intraoperative frozen section analysis of sentinel lymph nodes in breast cancer. / Chao, Celia; Wong, Sandra L.; Ackermann, Douglas; Simpson, Diana; Carter, Mary B.; Brown, C. Matthew; Edwards, Michael J.; McMasters, Kelly M.

In: American Journal of Surgery, Vol. 182, No. 6, 2001, p. 609-615.

Research output: Contribution to journalArticle

Chao, C, Wong, SL, Ackermann, D, Simpson, D, Carter, MB, Brown, CM, Edwards, MJ & McMasters, KM 2001, 'Utility of intraoperative frozen section analysis of sentinel lymph nodes in breast cancer', American Journal of Surgery, vol. 182, no. 6, pp. 609-615. https://doi.org/10.1016/S0002-9610(01)00794-2
Chao, Celia ; Wong, Sandra L. ; Ackermann, Douglas ; Simpson, Diana ; Carter, Mary B. ; Brown, C. Matthew ; Edwards, Michael J. ; McMasters, Kelly M. / Utility of intraoperative frozen section analysis of sentinel lymph nodes in breast cancer. In: American Journal of Surgery. 2001 ; Vol. 182, No. 6. pp. 609-615.
@article{822907775f884b5589069f1f2cbf0354,
title = "Utility of intraoperative frozen section analysis of sentinel lymph nodes in breast cancer",
abstract = "Background: Intraoperative frozen section pathologic analysis of sentinel lymph node (SLN) may guide immediate (single-stage) completion axillary dissection for patients with nodal metastases. Methods: The results of 203 consecutive patients undergoing SLN biopsy who had intraoperative pathology consultation between January 1998 and September 2000 were reviewed. SLN were analyzed by standard frozen section procedures. Final pathologic analysis included hematoxylin and eosin (H&E) staining of serial sections at 2-mm intervals. Results: Frozen section analysis correctly identified a positive or negative result in 185 of 203 cases (overall accuracy 91{\%}). In 17 of 53 cases, the SLNs were negative for tumor by frozen section, but positive on permanent section analysis (sensitivity 68{\%}). The mean size of the nodal metastases was 6.2 mm and 1.5 mm in patients found to have true positive and false negative results, respectively (P <0.003). A single false positive SLN is reported. Conclusions: Two thirds of the patients were spared the need for reoperative axillary lymphadenectomy.",
keywords = "Breast cancer, Frozen section, Sentinel lymph node",
author = "Celia Chao and Wong, {Sandra L.} and Douglas Ackermann and Diana Simpson and Carter, {Mary B.} and Brown, {C. Matthew} and Edwards, {Michael J.} and McMasters, {Kelly M.}",
year = "2001",
doi = "10.1016/S0002-9610(01)00794-2",
language = "English (US)",
volume = "182",
pages = "609--615",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Utility of intraoperative frozen section analysis of sentinel lymph nodes in breast cancer

AU - Chao, Celia

AU - Wong, Sandra L.

AU - Ackermann, Douglas

AU - Simpson, Diana

AU - Carter, Mary B.

AU - Brown, C. Matthew

AU - Edwards, Michael J.

AU - McMasters, Kelly M.

PY - 2001

Y1 - 2001

N2 - Background: Intraoperative frozen section pathologic analysis of sentinel lymph node (SLN) may guide immediate (single-stage) completion axillary dissection for patients with nodal metastases. Methods: The results of 203 consecutive patients undergoing SLN biopsy who had intraoperative pathology consultation between January 1998 and September 2000 were reviewed. SLN were analyzed by standard frozen section procedures. Final pathologic analysis included hematoxylin and eosin (H&E) staining of serial sections at 2-mm intervals. Results: Frozen section analysis correctly identified a positive or negative result in 185 of 203 cases (overall accuracy 91%). In 17 of 53 cases, the SLNs were negative for tumor by frozen section, but positive on permanent section analysis (sensitivity 68%). The mean size of the nodal metastases was 6.2 mm and 1.5 mm in patients found to have true positive and false negative results, respectively (P <0.003). A single false positive SLN is reported. Conclusions: Two thirds of the patients were spared the need for reoperative axillary lymphadenectomy.

AB - Background: Intraoperative frozen section pathologic analysis of sentinel lymph node (SLN) may guide immediate (single-stage) completion axillary dissection for patients with nodal metastases. Methods: The results of 203 consecutive patients undergoing SLN biopsy who had intraoperative pathology consultation between January 1998 and September 2000 were reviewed. SLN were analyzed by standard frozen section procedures. Final pathologic analysis included hematoxylin and eosin (H&E) staining of serial sections at 2-mm intervals. Results: Frozen section analysis correctly identified a positive or negative result in 185 of 203 cases (overall accuracy 91%). In 17 of 53 cases, the SLNs were negative for tumor by frozen section, but positive on permanent section analysis (sensitivity 68%). The mean size of the nodal metastases was 6.2 mm and 1.5 mm in patients found to have true positive and false negative results, respectively (P <0.003). A single false positive SLN is reported. Conclusions: Two thirds of the patients were spared the need for reoperative axillary lymphadenectomy.

KW - Breast cancer

KW - Frozen section

KW - Sentinel lymph node

UR - http://www.scopus.com/inward/record.url?scp=0035705404&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035705404&partnerID=8YFLogxK

U2 - 10.1016/S0002-9610(01)00794-2

DO - 10.1016/S0002-9610(01)00794-2

M3 - Article

C2 - 11839325

AN - SCOPUS:0035705404

VL - 182

SP - 609

EP - 615

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

IS - 6

ER -