Utilization of tetrabutylammonium triphenyldifluorosilicate (TBAT) in the synthesis of 6-fluoropurine nucleosides

Vadim Gurvich, Hye Young Kim, Richard P. Hodge, Constance M. Harris, Thomas M. Harris

    Research output: Contribution to journalArticle

    10 Scopus citations

    Abstract

    Tetrabutylammonium triphenydifluorosilicate (TBAT) has been found to be a useful reagent for the conversion of 6-chloropurine nucleosides to 6- fluoropurine derivatives. The 6-chloropurine nucleosides were reacted with trimethylamine to form quaternary trimethylammonium salts which were treated in situ with TBAT in DMF to effect conversion to the 6-fluoro derivatives in yields of 59-72%.

    Original languageEnglish (US)
    Pages (from-to)2327-2333
    Number of pages7
    JournalNucleosides and Nucleotides
    Volume18
    Issue number10
    DOIs
    StatePublished - Jan 1 1999

    ASJC Scopus subject areas

    • Biochemistry
    • Genetics

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