Vaccination with purified Dr fimbriae reduces mortality associated with chronic urinary tract infection due to Escherichia coli bearing Dr adhesin

Pawel Goluszko, Elzbieta Goluszko, Bogdan Nowicki, Stella Nowicki, Vsevolod Popov, Hui Qun Wang

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.

Original languageEnglish (US)
Pages (from-to)627-631
Number of pages5
JournalInfection and Immunity
Volume73
Issue number1
DOIs
StatePublished - Jan 2005

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Urinary Tract Infections
Vaccination
Escherichia coli
Kidney
Mortality
Inbred C3H Mouse
Immune Sera
Anti-Idiotypic Antibodies
Urinary Bladder
Antigens

ASJC Scopus subject areas

  • Immunology

Cite this

Vaccination with purified Dr fimbriae reduces mortality associated with chronic urinary tract infection due to Escherichia coli bearing Dr adhesin. / Goluszko, Pawel; Goluszko, Elzbieta; Nowicki, Bogdan; Nowicki, Stella; Popov, Vsevolod; Wang, Hui Qun.

In: Infection and Immunity, Vol. 73, No. 1, 01.2005, p. 627-631.

Research output: Contribution to journalArticle

Goluszko, Pawel ; Goluszko, Elzbieta ; Nowicki, Bogdan ; Nowicki, Stella ; Popov, Vsevolod ; Wang, Hui Qun. / Vaccination with purified Dr fimbriae reduces mortality associated with chronic urinary tract infection due to Escherichia coli bearing Dr adhesin. In: Infection and Immunity. 2005 ; Vol. 73, No. 1. pp. 627-631.
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