Vaccination with purified Dr fimbriae reduces mortality associated with chronic urinary tract infection due to Escherichia coli bearing Dr adhesin

Pawel Goluszko, Elzbieta Goluszko, Bogdan Nowicki, Stella Nowicki, Vsevolod Popov, Hui Qun Wang

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.

Original languageEnglish (US)
Pages (from-to)627-631
Number of pages5
JournalInfection and immunity
Volume73
Issue number1
DOIs
StatePublished - Jan 2005

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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