Vaccination with purified Dr fimbriae reduces mortality associated with chronic urinary tract infection due to Escherichia coli bearing Dr adhesin

Pawel Goluszko; Elzbieta Goluszko; Bogdan Nowicki; Stella Nowicki; Vsevolod Popov; Hui Qun Wang

doi:10.1128/IAI.73.1.627-631.2005

Vaccination with purified Dr fimbriae reduces mortality associated with chronic urinary tract infection due to Escherichia coli bearing Dr adhesin

Pawel Goluszko
, Elzbieta Goluszko
, Bogdan Nowicki
, Stella Nowicki
, Vsevolod Popov
, Hui Qun Wang

Pathology

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.

Original language	English (US)
Pages (from-to)	627-631
Number of pages	5
Journal	Infection and immunity
Volume	73
Issue number	1
DOIs	https://doi.org/10.1128/IAI.73.1.627-631.2005
State	Published - Jan 2005

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.73.1.627-631.2005

Cite this

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abstract = "The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.",

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AU - Goluszko, Pawel

AU - Goluszko, Elzbieta

AU - Nowicki, Bogdan

AU - Nowicki, Stella

AU - Popov, Vsevolod

AU - Wang, Hui Qun

PY - 2005/1

Y1 - 2005/1

N2 - The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.

AB - The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.

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U2 - 10.1128/IAI.73.1.627-631.2005

DO - 10.1128/IAI.73.1.627-631.2005

M3 - Article

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AN - SCOPUS:11144331374

SN - 0019-9567

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Vaccination with purified Dr fimbriae reduces mortality associated with chronic urinary tract infection due to Escherichia coli bearing Dr adhesin

Abstract

ASJC Scopus subject areas

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