@inbook{521fcaaa3e7448b9a75a865898d0d148,
title = "Vaccine Development Against Trypanosoma cruzi and Chagas Disease",
abstract = "The pathology of Chagas disease presents a complicated and diverse picture in humans. The major complications and destructive evolutionary outcomes of chronic infection by Trypanosoma cruzi in humans include ventricular fibrillation, thromboembolism and congestive heart failure. Studies in animal models and human patients have revealed the pathogenic mechanisms during disease progression, pathology of disease and features of protective immunity. Accordingly, several antigens, antigen-delivery vehicles and adjuvants have been tested to elicit immune protection to T. cruzi in experimental animals. This review summarizes the research efforts in vaccine development against Chagas disease during the past decade.",
keywords = "Adjuvants, Chagas, Immunity, Therapeutic and prophylactic vaccine, Trypanosoma cruzi",
author = "V{\'a}zquez-Chagoy{\'a}n, {Juan C.} and Shivali Gupta and Garg, {Nisha Jain}",
note = "Funding Information: The work in N. J. G.'s laboratory has been supported in part by grants from the American Heart Association, John Sealy Memorial Endowment Fund for Biomedical Research, American Health Assistance Foundation and National Institutes of Health. The work in J. C. V.-C.'s laboratory has been supported by the National Institute of Allergy and Infection Diseases and the Secretaria de Investigacion y Estudios Avanzados de la Universidad Aut{\'o}noma del Estado de M{\'e}xico. S. G. is an awardee of a postdoctoral fellowship from the Sealy Center of Vaccine Development. Our thanks are due to Ms. Mardelle Susman for proofreading and editing the chapter.",
year = "2011",
doi = "10.1016/B978-0-12-385863-4.00006-X",
language = "English (US)",
series = "Advances in Parasitology",
publisher = "Academic Press",
pages = "121--146",
booktitle = "Advances in Parasitology",
}