Vaccines and immunization strategies for dengue prevention

Yang Liu, Jianying Liu, Gong Cheng

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

Dengue is currently the most significant arboviral disease afflicting tropical and sub-tropical countries worldwide. Dengue vaccines, such as the multivalent attenuated, chimeric, DNA and inactivated vaccines, have been developed to prevent dengue infection in humans, and they function predominantly by stimulating immune responses against the dengue virus (DENV) envelope (E) and nonstructural-1 proteins (NS1). Of these vaccines, a live attenuated chimeric tetravalent DENV vaccine developed by Sanofi Pasteur has been licensed in several countries. However, this vaccine renders only partial protection against the DENV2 infection and is associated with an unexplained increased incidence of hospitalization for severe dengue disease among children younger than nine years old. In addition to the virus-based vaccines, several mosquito-based dengue immunization strategies have been developed to interrupt the vector competence and effectively reduce the number of infected mosquito vectors, thus controlling the transmission of DENV in nature. Here we summarize the recent progress in the development of dengue vaccines and novel immunization strategies and propose some prospective vaccine strategies for disease prevention in the future. Emerging Microbes and Infections (2016) 5, e77; doi:10.1038/emi.2016.74; published online 20 July 2016.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalEmerging Microbes and Infections
Volume5
Issue number1
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • NS1-based immunization strategies
  • dengue virus
  • mosquito-based immunization strategies
  • vaccine

ASJC Scopus subject areas

  • Parasitology
  • Epidemiology
  • Microbiology
  • Immunology
  • Drug Discovery
  • Virology
  • Infectious Diseases

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