Vaccines for Venezuelan equine encephalitis

Slobodan Paessler; Scott C. Weaver

doi:10.1016/j.vaccine.2009.07.095

Vaccines for Venezuelan equine encephalitis

Slobodan Paessler, Scott C. Weaver

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

Arboviruses are capable of causing encephalitis in animals and human population when transmitted by the vector or potentially via infectious aerosol. Recent re-emergence of Venezuelan equine encephalitis virus (VEEV) in South America emphasizes the importance of this pathogen to public health and veterinary medicine. Despite its importance no antivirals or vaccines against VEEV are currently available in the USA. Here we review some of the older and newer approaches aimed at generating a safe and immunogenic vaccine as well as most recent data about the mechanistic of protection in animal models of infection.

Original language	English (US)
Pages (from-to)	D80-D85
Journal	Vaccine
Volume	27
Issue number	SUPPL. 4
DOIs	https://doi.org/10.1016/j.vaccine.2009.07.095
State	Published - Nov 5 2009

Keywords

Encephalitis
Togaviridae
Vaccines

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2009.07.095

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title = "Vaccines for Venezuelan equine encephalitis",

abstract = "Arboviruses are capable of causing encephalitis in animals and human population when transmitted by the vector or potentially via infectious aerosol. Recent re-emergence of Venezuelan equine encephalitis virus (VEEV) in South America emphasizes the importance of this pathogen to public health and veterinary medicine. Despite its importance no antivirals or vaccines against VEEV are currently available in the USA. Here we review some of the older and newer approaches aimed at generating a safe and immunogenic vaccine as well as most recent data about the mechanistic of protection in animal models of infection.",

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AU - Weaver, Scott C.

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AB - Arboviruses are capable of causing encephalitis in animals and human population when transmitted by the vector or potentially via infectious aerosol. Recent re-emergence of Venezuelan equine encephalitis virus (VEEV) in South America emphasizes the importance of this pathogen to public health and veterinary medicine. Despite its importance no antivirals or vaccines against VEEV are currently available in the USA. Here we review some of the older and newer approaches aimed at generating a safe and immunogenic vaccine as well as most recent data about the mechanistic of protection in animal models of infection.

KW - Encephalitis

KW - Togaviridae

KW - Vaccines

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JF - Vaccine

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Vaccines for Venezuelan equine encephalitis

Abstract

Keywords

ASJC Scopus subject areas

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