Validation in volunteers of a near-infrared spectroscope for monitoring brain oxygenation in vivo

Valerie Pollard, Donald Prough, A. Eric DeMelo, Donald J. Deyo, Tatsuo Uchida, Hugh F. Stoddart

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

Cerebral oximeters based on near-infrared spectroscopy may provide a continuous, noninvasive assessment of cerebral oxygenation. We evaluated a prototype cerebral oximeter (Invos 3100; Somanetics, Troy, MI) in 22 conscious, healthy volunteers breathing hypoxic gas mixtures. Using the first 12 subjects (training group), we developed an algorithm based on the mathematic relationship that converts detected light from the field surveyed by the probe to cerebral hemoglobin oxygen saturation (CS(f)O 2). To develop the algorithm, we correlated the oximeter result with the estimated combined brain hemoglobin oxygen saturation (CS(comb)O 2, where CS(comb)O 2 = S(a)O 2 x 0.25 + S(j)O 2 x 0.75 and S(i)O 2 = jugular venous saturation). We then validated the algorithm in the remaining 10 volunteers (validation group). A close association (r 2 = 0.7980.987 for individuals in the training group and r 2 = 0.794-0.992 for individuals in the validation group) existed between CS(f)O 2 and Cs(comb)O 2. We conclude that continuous monitoring with cerebral oximetry may accurately recognize decreasing cerebral hemoglobin oxygen saturation produced by systemic hypoxemia.

Original languageEnglish (US)
Pages (from-to)269-277
Number of pages9
JournalAnesthesia and Analgesia
Volume82
Issue number2
DOIs
StatePublished - 1996

Fingerprint

Comb and Wattles
Volunteers
Hemoglobins
Oxygen
Brain
Oximetry
Near-Infrared Spectroscopy
Mathematics
Healthy Volunteers
Respiration
Neck
Light

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Validation in volunteers of a near-infrared spectroscope for monitoring brain oxygenation in vivo. / Pollard, Valerie; Prough, Donald; Eric DeMelo, A.; Deyo, Donald J.; Uchida, Tatsuo; Stoddart, Hugh F.

In: Anesthesia and Analgesia, Vol. 82, No. 2, 1996, p. 269-277.

Research output: Contribution to journalArticle

Pollard, Valerie ; Prough, Donald ; Eric DeMelo, A. ; Deyo, Donald J. ; Uchida, Tatsuo ; Stoddart, Hugh F. / Validation in volunteers of a near-infrared spectroscope for monitoring brain oxygenation in vivo. In: Anesthesia and Analgesia. 1996 ; Vol. 82, No. 2. pp. 269-277.
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