Abstract
Background & aims: Postprandial lipemia is assessed using the oral fat tolerance test (OFTT), a six-hour procedure requiring hourly blood sampling. In order to simplify the test, we investigated whether a) a single postprandial triacylglycerol concentration, b) an OFTT lasting less than six hours or c) an OFTT requiring fewer blood samples, may accurately assess postprandial lipemia under various conditions. Methods: Seventy-two subjects underwent a conventional OFTT. Predictability of single-point concentrations and time-shortened tests was assessed using linear regression and re-sampling analysis. Validity of reduced-sampling tests was assessed using Pearson's correlation coefficients and Bland-Altman analysis. Results: a) A single-point triacylglycerol concentration (3 or 4h postprandially) did not present significant correlation with postprandial lipemia in the hypetriacylglycerolemic, exercise and energy restriction groups (P>0.05), b) Time-shortened OFTT (4h) was able to predict postprandial lipemia in every group studied (R 2=0.707-0.970, P<0.01), except the hypertriacylglycerolemics (P=0.338), c) Reduced-sampling OFTT (3 or 4 samples) was able to assess postprandial lipemia in every group as well as in the overall sample (r=0.874-0.997, P<0.05). Conclusions: A more convenient, reduced-sampling OFTT may be used alternatively to the conventional OFTT, whereas a time-shortened OFTT may be appropriate only for healthy people.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 852-857 |
| Number of pages | 6 |
| Journal | Clinical Nutrition |
| Volume | 30 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2011 |
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Keywords
- Clinical testing
- Lipid metabolism
- Triglyceride
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
- Nutrition and Dietetics
Cite this
Validity of abbreviated oral fat tolerance tests for assessing postprandial lipemia. / Maraki, Maria; Aggelopoulou, Niki; Christodoulou, Nektarios; Katsarou, Christina; Anapliotis, Panagiotis; Kavouras, Stavros A.; Panagiotakos, Demosthenes; Sidossis, Labros S.
In: Clinical Nutrition, Vol. 30, No. 6, 12.2011, p. 852-857.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Validity of abbreviated oral fat tolerance tests for assessing postprandial lipemia
AU - Maraki, Maria
AU - Aggelopoulou, Niki
AU - Christodoulou, Nektarios
AU - Katsarou, Christina
AU - Anapliotis, Panagiotis
AU - Kavouras, Stavros A.
AU - Panagiotakos, Demosthenes
AU - Sidossis, Labros S.
PY - 2011/12
Y1 - 2011/12
N2 - Background & aims: Postprandial lipemia is assessed using the oral fat tolerance test (OFTT), a six-hour procedure requiring hourly blood sampling. In order to simplify the test, we investigated whether a) a single postprandial triacylglycerol concentration, b) an OFTT lasting less than six hours or c) an OFTT requiring fewer blood samples, may accurately assess postprandial lipemia under various conditions. Methods: Seventy-two subjects underwent a conventional OFTT. Predictability of single-point concentrations and time-shortened tests was assessed using linear regression and re-sampling analysis. Validity of reduced-sampling tests was assessed using Pearson's correlation coefficients and Bland-Altman analysis. Results: a) A single-point triacylglycerol concentration (3 or 4h postprandially) did not present significant correlation with postprandial lipemia in the hypetriacylglycerolemic, exercise and energy restriction groups (P>0.05), b) Time-shortened OFTT (4h) was able to predict postprandial lipemia in every group studied (R 2=0.707-0.970, P<0.01), except the hypertriacylglycerolemics (P=0.338), c) Reduced-sampling OFTT (3 or 4 samples) was able to assess postprandial lipemia in every group as well as in the overall sample (r=0.874-0.997, P<0.05). Conclusions: A more convenient, reduced-sampling OFTT may be used alternatively to the conventional OFTT, whereas a time-shortened OFTT may be appropriate only for healthy people.
AB - Background & aims: Postprandial lipemia is assessed using the oral fat tolerance test (OFTT), a six-hour procedure requiring hourly blood sampling. In order to simplify the test, we investigated whether a) a single postprandial triacylglycerol concentration, b) an OFTT lasting less than six hours or c) an OFTT requiring fewer blood samples, may accurately assess postprandial lipemia under various conditions. Methods: Seventy-two subjects underwent a conventional OFTT. Predictability of single-point concentrations and time-shortened tests was assessed using linear regression and re-sampling analysis. Validity of reduced-sampling tests was assessed using Pearson's correlation coefficients and Bland-Altman analysis. Results: a) A single-point triacylglycerol concentration (3 or 4h postprandially) did not present significant correlation with postprandial lipemia in the hypetriacylglycerolemic, exercise and energy restriction groups (P>0.05), b) Time-shortened OFTT (4h) was able to predict postprandial lipemia in every group studied (R 2=0.707-0.970, P<0.01), except the hypertriacylglycerolemics (P=0.338), c) Reduced-sampling OFTT (3 or 4 samples) was able to assess postprandial lipemia in every group as well as in the overall sample (r=0.874-0.997, P<0.05). Conclusions: A more convenient, reduced-sampling OFTT may be used alternatively to the conventional OFTT, whereas a time-shortened OFTT may be appropriate only for healthy people.
KW - Clinical testing
KW - Lipid metabolism
KW - Triglyceride
UR - http://www.scopus.com/inward/record.url?scp=82255163005&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82255163005&partnerID=8YFLogxK
U2 - 10.1016/j.clnu.2011.05.003
DO - 10.1016/j.clnu.2011.05.003
M3 - Article
VL - 30
SP - 852
EP - 857
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 6
ER -