Validity of abbreviated oral fat tolerance tests for assessing postprandial lipemia

Maria Maraki, Niki Aggelopoulou, Nektarios Christodoulou, Christina Katsarou, Panagiotis Anapliotis, Stavros A. Kavouras, Demosthenes Panagiotakos, Labros S. Sidossis

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Background & aims: Postprandial lipemia is assessed using the oral fat tolerance test (OFTT), a six-hour procedure requiring hourly blood sampling. In order to simplify the test, we investigated whether a) a single postprandial triacylglycerol concentration, b) an OFTT lasting less than six hours or c) an OFTT requiring fewer blood samples, may accurately assess postprandial lipemia under various conditions. Methods: Seventy-two subjects underwent a conventional OFTT. Predictability of single-point concentrations and time-shortened tests was assessed using linear regression and re-sampling analysis. Validity of reduced-sampling tests was assessed using Pearson's correlation coefficients and Bland-Altman analysis. Results: a) A single-point triacylglycerol concentration (3 or 4h postprandially) did not present significant correlation with postprandial lipemia in the hypetriacylglycerolemic, exercise and energy restriction groups (P>0.05), b) Time-shortened OFTT (4h) was able to predict postprandial lipemia in every group studied (R 2=0.707-0.970, P<0.01), except the hypertriacylglycerolemics (P=0.338), c) Reduced-sampling OFTT (3 or 4 samples) was able to assess postprandial lipemia in every group as well as in the overall sample (r=0.874-0.997, P<0.05). Conclusions: A more convenient, reduced-sampling OFTT may be used alternatively to the conventional OFTT, whereas a time-shortened OFTT may be appropriate only for healthy people.

Original languageEnglish (US)
Pages (from-to)852-857
Number of pages6
JournalClinical Nutrition
Volume30
Issue number6
DOIs
StatePublished - Dec 1 2011

Keywords

  • Clinical testing
  • Lipid metabolism
  • Triglyceride

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Critical Care and Intensive Care Medicine

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    Maraki, M., Aggelopoulou, N., Christodoulou, N., Katsarou, C., Anapliotis, P., Kavouras, S. A., Panagiotakos, D., & Sidossis, L. S. (2011). Validity of abbreviated oral fat tolerance tests for assessing postprandial lipemia. Clinical Nutrition, 30(6), 852-857. https://doi.org/10.1016/j.clnu.2011.05.003