Variability in human sensitivity to 1,3-butadiene: Influence of polymorphisms in the 5′-flanking region of the microsomal epoxide hydrolase gene (EPHX1)

Keyphrases

• Polymorphism 100%
• 5′-flanking Region 100%
• Soluble Epoxide Hydrolase 100%
• 1,3-Butadiene 100%
• Human Sensitivity 100%
• EPHX1 100%
• Variant Frequency 70%
• Genotoxic Effect 20%
• Epoxides 20%
• Enzymatic Activity 20%
• Occupational Exposure 10%
• Lymphocytes 10%
• Genotype 10%
• Transcriptional Activity 10%
• Statistical Model 10%
• Southeast Texas 10%
• Non-smoking 10%
• Positive Interactions 10%
• Synthetic Rubber 10%
• Adverse Health Effects 10%
• Linkage Pattern 10%
• Hydrolase Activity 10%
• Linkage Group 10%
• Styrene-butadiene Rubber 10%
• Mutant Variants 10%
• Detoxification Capacity 10%
• First-order Interaction 10%
• 4-way 10%
• Polymorphic Site 10%
• Carcinogenic Effect 10%
• Coding Region Polymorphism 10%

Biochemistry, Genetics and Molecular Biology

• DNA Flanking Region 100%
• Microsomal Epoxide Hydrolase 100%
• EPHX1 100%
• Gene Linkage 50%
• Allele 20%
• Enzyme Activity 20%
• Enzymatic Hydrolysis 10%
• Metabolite 10%
• Enzyme 10%
• Coding Region 10%
• Scanning Electron Microscopy 10%
• Genetic Linkage 10%
• Lymphocyte 10%
• Inheritance 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Epoxide Hydrolase 100%
• 1,3-Butadiene 100%
• Epoxide 20%
• Biological Marker 10%
• Occupational Exposure 10%
• Scanning Electron Microscopy 10%
• Detoxication 10%
• Enzymes 10%
• Styrene 10%