Variable clinical features and ablation of manifest nodofascicular/ventricular pathways

Kurt S. Hoffmayer, Byron K. Lee, Vasanth Vedantham, Ashish A. Bhimani, Ivan T. Cakulev, Judith A. Mackall, Jayakumar Sahadevan, Robert W. Rho, Melvin M. Scheinman

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background - Manifest nodofascicular/ventricular (NFV) pathways are rare. Methods and Results - From 2008 to 2013, 4 cases were identified with manifest NFV pathways from 3 centers. The clinical findings and ablation sites are reported. All 4 cases presented with a wide complex tachycardia but with different QRS morphologies. Case 1 showed a left bundle branch block/superior axis, case 2 showed a right bundle branch block/inferior axis, case 3 showed a left bundle branch block/inferior axis, and case 4 showed a narrow QRS tachycardia and a wide complex tachycardia with a left bundle branch block/inferior axis. Three of the 4 tachycardias had atrioventricular dissociation ruling out extranodal accessory pathways, including atriofascicular pathways. Programmed extrastimuli showed evidence of a decremental accessory pathway in 3 of the 4 cases. Coexisting tachycardia mechanisms were seen in 3 of the 4 cases (atrioventricular nodal reentry tachycardia [2] and atrioventricular reentrant tachycardia [1]). Ablation in the slow pathway region eliminated the NFV pathway in 3 (transient in 1) with the other responding to surgical closure of a large atrial septal defect. The NFV pathway was a critical part of the tachycardia circuit in 1 and proved to be a bystander in the other 3 cases. Conclusions - Manifest NFV pathways presented with variable QRS expression dependent on the ventricular insertion site and often coexisted with other tachycardia mechanisms (atrioventricular nodal reentry tachycardia and atrioventricular reentrant tachycardia). In most cases, the atrial insertion of the pathway was in or near the slow pathway region. The NFV pathways were either critical to the tachycardia circuit or served as bystanders.

Original languageEnglish (US)
Pages (from-to)117-127
Number of pages11
JournalCirculation: Arrhythmia and Electrophysiology
Volume8
Issue number1
DOIs
StatePublished - Feb 28 2015
Externally publishedYes

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Tachycardia
Bundle-Branch Block
Atrioventricular Nodal Reentry Tachycardia
Heart Block
Atrial Heart Septal Defects

Keywords

  • catheter ablation
  • electrophysiology
  • tachycardia, supraventricular

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Medicine(all)

Cite this

Hoffmayer, K. S., Lee, B. K., Vedantham, V., Bhimani, A. A., Cakulev, I. T., Mackall, J. A., ... Scheinman, M. M. (2015). Variable clinical features and ablation of manifest nodofascicular/ventricular pathways. Circulation: Arrhythmia and Electrophysiology, 8(1), 117-127. https://doi.org/10.1161/CIRCEP.114.001924

Variable clinical features and ablation of manifest nodofascicular/ventricular pathways. / Hoffmayer, Kurt S.; Lee, Byron K.; Vedantham, Vasanth; Bhimani, Ashish A.; Cakulev, Ivan T.; Mackall, Judith A.; Sahadevan, Jayakumar; Rho, Robert W.; Scheinman, Melvin M.

In: Circulation: Arrhythmia and Electrophysiology, Vol. 8, No. 1, 28.02.2015, p. 117-127.

Research output: Contribution to journalArticle

Hoffmayer, KS, Lee, BK, Vedantham, V, Bhimani, AA, Cakulev, IT, Mackall, JA, Sahadevan, J, Rho, RW & Scheinman, MM 2015, 'Variable clinical features and ablation of manifest nodofascicular/ventricular pathways', Circulation: Arrhythmia and Electrophysiology, vol. 8, no. 1, pp. 117-127. https://doi.org/10.1161/CIRCEP.114.001924
Hoffmayer, Kurt S. ; Lee, Byron K. ; Vedantham, Vasanth ; Bhimani, Ashish A. ; Cakulev, Ivan T. ; Mackall, Judith A. ; Sahadevan, Jayakumar ; Rho, Robert W. ; Scheinman, Melvin M. / Variable clinical features and ablation of manifest nodofascicular/ventricular pathways. In: Circulation: Arrhythmia and Electrophysiology. 2015 ; Vol. 8, No. 1. pp. 117-127.
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abstract = "Background - Manifest nodofascicular/ventricular (NFV) pathways are rare. Methods and Results - From 2008 to 2013, 4 cases were identified with manifest NFV pathways from 3 centers. The clinical findings and ablation sites are reported. All 4 cases presented with a wide complex tachycardia but with different QRS morphologies. Case 1 showed a left bundle branch block/superior axis, case 2 showed a right bundle branch block/inferior axis, case 3 showed a left bundle branch block/inferior axis, and case 4 showed a narrow QRS tachycardia and a wide complex tachycardia with a left bundle branch block/inferior axis. Three of the 4 tachycardias had atrioventricular dissociation ruling out extranodal accessory pathways, including atriofascicular pathways. Programmed extrastimuli showed evidence of a decremental accessory pathway in 3 of the 4 cases. Coexisting tachycardia mechanisms were seen in 3 of the 4 cases (atrioventricular nodal reentry tachycardia [2] and atrioventricular reentrant tachycardia [1]). Ablation in the slow pathway region eliminated the NFV pathway in 3 (transient in 1) with the other responding to surgical closure of a large atrial septal defect. The NFV pathway was a critical part of the tachycardia circuit in 1 and proved to be a bystander in the other 3 cases. Conclusions - Manifest NFV pathways presented with variable QRS expression dependent on the ventricular insertion site and often coexisted with other tachycardia mechanisms (atrioventricular nodal reentry tachycardia and atrioventricular reentrant tachycardia). In most cases, the atrial insertion of the pathway was in or near the slow pathway region. The NFV pathways were either critical to the tachycardia circuit or served as bystanders.",
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AU - Hoffmayer, Kurt S.

AU - Lee, Byron K.

AU - Vedantham, Vasanth

AU - Bhimani, Ashish A.

AU - Cakulev, Ivan T.

AU - Mackall, Judith A.

AU - Sahadevan, Jayakumar

AU - Rho, Robert W.

AU - Scheinman, Melvin M.

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N2 - Background - Manifest nodofascicular/ventricular (NFV) pathways are rare. Methods and Results - From 2008 to 2013, 4 cases were identified with manifest NFV pathways from 3 centers. The clinical findings and ablation sites are reported. All 4 cases presented with a wide complex tachycardia but with different QRS morphologies. Case 1 showed a left bundle branch block/superior axis, case 2 showed a right bundle branch block/inferior axis, case 3 showed a left bundle branch block/inferior axis, and case 4 showed a narrow QRS tachycardia and a wide complex tachycardia with a left bundle branch block/inferior axis. Three of the 4 tachycardias had atrioventricular dissociation ruling out extranodal accessory pathways, including atriofascicular pathways. Programmed extrastimuli showed evidence of a decremental accessory pathway in 3 of the 4 cases. Coexisting tachycardia mechanisms were seen in 3 of the 4 cases (atrioventricular nodal reentry tachycardia [2] and atrioventricular reentrant tachycardia [1]). Ablation in the slow pathway region eliminated the NFV pathway in 3 (transient in 1) with the other responding to surgical closure of a large atrial septal defect. The NFV pathway was a critical part of the tachycardia circuit in 1 and proved to be a bystander in the other 3 cases. Conclusions - Manifest NFV pathways presented with variable QRS expression dependent on the ventricular insertion site and often coexisted with other tachycardia mechanisms (atrioventricular nodal reentry tachycardia and atrioventricular reentrant tachycardia). In most cases, the atrial insertion of the pathway was in or near the slow pathway region. The NFV pathways were either critical to the tachycardia circuit or served as bystanders.

AB - Background - Manifest nodofascicular/ventricular (NFV) pathways are rare. Methods and Results - From 2008 to 2013, 4 cases were identified with manifest NFV pathways from 3 centers. The clinical findings and ablation sites are reported. All 4 cases presented with a wide complex tachycardia but with different QRS morphologies. Case 1 showed a left bundle branch block/superior axis, case 2 showed a right bundle branch block/inferior axis, case 3 showed a left bundle branch block/inferior axis, and case 4 showed a narrow QRS tachycardia and a wide complex tachycardia with a left bundle branch block/inferior axis. Three of the 4 tachycardias had atrioventricular dissociation ruling out extranodal accessory pathways, including atriofascicular pathways. Programmed extrastimuli showed evidence of a decremental accessory pathway in 3 of the 4 cases. Coexisting tachycardia mechanisms were seen in 3 of the 4 cases (atrioventricular nodal reentry tachycardia [2] and atrioventricular reentrant tachycardia [1]). Ablation in the slow pathway region eliminated the NFV pathway in 3 (transient in 1) with the other responding to surgical closure of a large atrial septal defect. The NFV pathway was a critical part of the tachycardia circuit in 1 and proved to be a bystander in the other 3 cases. Conclusions - Manifest NFV pathways presented with variable QRS expression dependent on the ventricular insertion site and often coexisted with other tachycardia mechanisms (atrioventricular nodal reentry tachycardia and atrioventricular reentrant tachycardia). In most cases, the atrial insertion of the pathway was in or near the slow pathway region. The NFV pathways were either critical to the tachycardia circuit or served as bystanders.

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KW - electrophysiology

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