Variation in aedes aegypti mosquito competence for zika virus transmission

Christopher M. Roundy, Sasha R. Azar, Shannan Rossi, Jing H. Huang, Grace Leal, Ruimei Yun, Ildefonso Fernandez-Salas, Christopher J. Vitek, Igor A D Paploski, Uriel Kitron, Guilherme S. Ribeiro, Kathryn A. Hanley, Scott Weaver, Nikos Vasilakis

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

To test whether Zika virus has adapted for more efficient transmission by Aedes aegypti mosquitoes, leading to recent urban outbreaks, we fed mosquitoes from Brazil, the Dominican Republic, and the United States artificial blood meals containing 1 of 3 Zika virus strains (Senegal, Cambodia, Mexico) and monitored infection, dissemination, and virus in saliva. Contrary to our hypothesis, Cambodia and Mexica strains were less infectious than the Senegal strain. Only mosquitoes from the Dominican Republic transmitted the Cambodia and Mexica strains. However, blood meals from viremic mice were more infectious than artificial blood meals of comparable doses; the Cambodia strain was not transmitted by mosquitoes from Brazil after artificial blood meals, whereas 61% transmission occurred after a murine blood meal (saliva titers up to 4 log10 infectious units/collection). Although regional origins of vector populations and virus strain influence transmission efficiency, Ae. aegypti mosquitoes appear to be competent vectors of Zika virus in several regions of the Americas.

Original languageEnglish (US)
Pages (from-to)625-632
Number of pages8
JournalEmerging Infectious Diseases
Volume23
Issue number4
DOIs
StatePublished - Apr 1 2017

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Aedes
Cambodia
Culicidae
Mental Competency
Meals
Blood Substitutes
Dominican Republic
Senegal
Saliva
Brazil
Virus Diseases
Mexico
Disease Outbreaks
Zika Virus
Viruses
Population

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Variation in aedes aegypti mosquito competence for zika virus transmission. / Roundy, Christopher M.; Azar, Sasha R.; Rossi, Shannan; Huang, Jing H.; Leal, Grace; Yun, Ruimei; Fernandez-Salas, Ildefonso; Vitek, Christopher J.; Paploski, Igor A D; Kitron, Uriel; Ribeiro, Guilherme S.; Hanley, Kathryn A.; Weaver, Scott; Vasilakis, Nikos.

In: Emerging Infectious Diseases, Vol. 23, No. 4, 01.04.2017, p. 625-632.

Research output: Contribution to journalArticle

Roundy, CM, Azar, SR, Rossi, S, Huang, JH, Leal, G, Yun, R, Fernandez-Salas, I, Vitek, CJ, Paploski, IAD, Kitron, U, Ribeiro, GS, Hanley, KA, Weaver, S & Vasilakis, N 2017, 'Variation in aedes aegypti mosquito competence for zika virus transmission', Emerging Infectious Diseases, vol. 23, no. 4, pp. 625-632. https://doi.org/10.3201/eid2304.161484
Roundy, Christopher M. ; Azar, Sasha R. ; Rossi, Shannan ; Huang, Jing H. ; Leal, Grace ; Yun, Ruimei ; Fernandez-Salas, Ildefonso ; Vitek, Christopher J. ; Paploski, Igor A D ; Kitron, Uriel ; Ribeiro, Guilherme S. ; Hanley, Kathryn A. ; Weaver, Scott ; Vasilakis, Nikos. / Variation in aedes aegypti mosquito competence for zika virus transmission. In: Emerging Infectious Diseases. 2017 ; Vol. 23, No. 4. pp. 625-632.
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