Variation in Protein Origin and Utilization

Research and Clinical Application

Douglas Paddon-Jones, Jorge A. Coss-Bu, Claudia R. Morris, Stuart M. Phillips, Jan Wernerman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Muscle health can be rapidly compromised in clinical environments. Modifiable strategies to preserve metabolic homeostasis in adult patient populations include physical activity and pharmacologic support; however, optimizing dietary practices, or more specifically protein intake, is a necessary prerequisite for any other treatment strategy to be fully effective. Simply increasing protein intake is a well-intentioned but often unfocused strategy to protect muscle health in an intensive care setting. Protein quality is a frequently overlooked factor with the potential to differentially influence health outcomes. Quality can be assessed by a variety of techniques, with digestible indispensable amino acid score being the current and most comprehensive technique endorsed by the Food and Agriculture Organization. In practical terms, animal-based proteins are consistently scored higher in quality compared with incomplete proteins, regardless of the assessment method. Consequently, choosing parenteral and/or enteral feeding options that contain high-quality proteins, rich in the branched-chain amino acid leucine, may help establish a dietary framework with the potential to support clinical practice and improve health outcomes in critically ill patients.

Original languageEnglish (US)
Pages (from-to)48S-57S
JournalNutrition in Clinical Practice
Volume32
Issue number1_suppl
DOIs
StatePublished - Apr 1 2017

Fingerprint

Research
Proteins
Health
Muscles
Branched Chain Amino Acids
Parenteral Nutrition
Enteral Nutrition
Critical Care
Agriculture
Critical Illness
Leucine
Homeostasis
Exercise
Amino Acids
Food
Population
Therapeutics

Keywords

  • amino acids
  • critical care
  • intensive care units
  • muscle protein synthesis
  • nutrition
  • protein quality
  • skeletal muscle

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Variation in Protein Origin and Utilization : Research and Clinical Application. / Paddon-Jones, Douglas; Coss-Bu, Jorge A.; Morris, Claudia R.; Phillips, Stuart M.; Wernerman, Jan.

In: Nutrition in Clinical Practice, Vol. 32, No. 1_suppl, 01.04.2017, p. 48S-57S.

Research output: Contribution to journalArticle

Paddon-Jones, Douglas ; Coss-Bu, Jorge A. ; Morris, Claudia R. ; Phillips, Stuart M. ; Wernerman, Jan. / Variation in Protein Origin and Utilization : Research and Clinical Application. In: Nutrition in Clinical Practice. 2017 ; Vol. 32, No. 1_suppl. pp. 48S-57S.
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