Variation in the susceptibility of strains of Staphylococcus aureus to oxacillin, cephalothin, and gentamicin

C. G. Mayhall, G. Medoff, J. J. Marr

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Three cases of staphylococcal bacteremia caused by organisms that were inhibited by low concentrations of oxacillin, but were resistant to the killing effects of oxacillin, stimulated the authors to screen 60 clinical isolates of Staphylococcus aureus for their susceptibility to oxacillin, cephalothin, and gentamicin. All 60 strains were inhibited by low concentrations of the antibiotics. The antibiotics were bactericidal against 27 of the 60 strains and only bacteriostatic against the other 33 after 24 h of incubation. However, after 48 h of incubation, the antibiotics were also bactericidal against the latter group.

Original languageEnglish (US)
Pages (from-to)707-712
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume10
Issue number4
DOIs
StatePublished - Jan 1 1976

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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