Variation in the susceptibility of strains of Staphylococcus aureus to oxacillin, cephalothin, and gentamicin

C. G. Mayhall, G. Medoff, J. J. Marr

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Three cases of staphylococcal bacteremia caused by organisms that were inhibited by low concentrations of oxacillin, but were resistant to the killing effects of oxacillin, stimulated the authors to screen 60 clinical isolates of Staphylococcus aureus for their susceptibility to oxacillin, cephalothin, and gentamicin. All 60 strains were inhibited by low concentrations of the antibiotics. The antibiotics were bactericidal against 27 of the 60 strains and only bacteriostatic against the other 33 after 24 h of incubation. However, after 48 h of incubation, the antibiotics were also bactericidal against the latter group.

Original languageEnglish (US)
Pages (from-to)707-712
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume10
Issue number4
StatePublished - 1976
Externally publishedYes

Fingerprint

Cephalothin
Oxacillin
Gentamicins
Staphylococcus aureus
Anti-Bacterial Agents
Bacteremia

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Variation in the susceptibility of strains of Staphylococcus aureus to oxacillin, cephalothin, and gentamicin. / Mayhall, C. G.; Medoff, G.; Marr, J. J.

In: Antimicrobial Agents and Chemotherapy, Vol. 10, No. 4, 1976, p. 707-712.

Research output: Contribution to journalArticle

@article{7d72ce37fcd140369daeed20eea76f55,
title = "Variation in the susceptibility of strains of Staphylococcus aureus to oxacillin, cephalothin, and gentamicin",
abstract = "Three cases of staphylococcal bacteremia caused by organisms that were inhibited by low concentrations of oxacillin, but were resistant to the killing effects of oxacillin, stimulated the authors to screen 60 clinical isolates of Staphylococcus aureus for their susceptibility to oxacillin, cephalothin, and gentamicin. All 60 strains were inhibited by low concentrations of the antibiotics. The antibiotics were bactericidal against 27 of the 60 strains and only bacteriostatic against the other 33 after 24 h of incubation. However, after 48 h of incubation, the antibiotics were also bactericidal against the latter group.",
author = "Mayhall, {C. G.} and G. Medoff and Marr, {J. J.}",
year = "1976",
language = "English (US)",
volume = "10",
pages = "707--712",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "4",

}

TY - JOUR

T1 - Variation in the susceptibility of strains of Staphylococcus aureus to oxacillin, cephalothin, and gentamicin

AU - Mayhall, C. G.

AU - Medoff, G.

AU - Marr, J. J.

PY - 1976

Y1 - 1976

N2 - Three cases of staphylococcal bacteremia caused by organisms that were inhibited by low concentrations of oxacillin, but were resistant to the killing effects of oxacillin, stimulated the authors to screen 60 clinical isolates of Staphylococcus aureus for their susceptibility to oxacillin, cephalothin, and gentamicin. All 60 strains were inhibited by low concentrations of the antibiotics. The antibiotics were bactericidal against 27 of the 60 strains and only bacteriostatic against the other 33 after 24 h of incubation. However, after 48 h of incubation, the antibiotics were also bactericidal against the latter group.

AB - Three cases of staphylococcal bacteremia caused by organisms that were inhibited by low concentrations of oxacillin, but were resistant to the killing effects of oxacillin, stimulated the authors to screen 60 clinical isolates of Staphylococcus aureus for their susceptibility to oxacillin, cephalothin, and gentamicin. All 60 strains were inhibited by low concentrations of the antibiotics. The antibiotics were bactericidal against 27 of the 60 strains and only bacteriostatic against the other 33 after 24 h of incubation. However, after 48 h of incubation, the antibiotics were also bactericidal against the latter group.

UR - http://www.scopus.com/inward/record.url?scp=0017190295&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017190295&partnerID=8YFLogxK

M3 - Article

C2 - 984804

AN - SCOPUS:0017190295

VL - 10

SP - 707

EP - 712

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 4

ER -