Variation trend of the tetrapeptide on the tip of V3 loop of 62 HIV-1 strains isolated in idu of Yunnan from 1990 to 1997

Hong Wu, Bin Wang, Rong Fang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective To investigate the variation trend of the amino acid and the corresponding nucleotide sequences of the tetrapeptide on the tip of the V3 loop of HIV-1 strains from intravenous drug users (IDUs) in Yunnan as time goes by. Methods According to the nucleotide sequences of the C2-V3 region of 62 HIV-1 strains isolated from intravenous drug users (IDUs) of Yunnan from 1990 to 1997, the nucleotide sequences of the tetrapeptide on the tip of the V3 loop of HIV-1 envelope protein were analysed. The variation trends with time were discussed. Results The tetrapeptides on the tip of the V3 loop of 62 Yunnan HIV-1 strains showed different amino acid variation with the major one at the fourth amino acid. Moreover, the variation tend to be in a similar pattern. Among the 62 isolated strains, 46 (74.2% ) showed the GPGR tetrapeptide motif, 10 (16.1 %) GPER motif, 4 (6.4%) GPGK motif and 2 (3.3%) GPER motif respectively. The variation at corresponding nucleotide sequence of the tetrapeptide motif was A→G. Conclusion In the period of 1990-1997, the tetrapeptides on the tip of the V3 loop of the HIV-1 strains from infected IDUs people in Yunnan are similar, and the results conform to the GPGR motif pattern of the international B subtype HIV-1SF2 strain.

Original languageEnglish (US)
Pages (from-to)462-464
Number of pages3
JournalChinese Journal of Microbiology and Immunology
Volume20
Issue number5
StatePublished - Sep 2000
Externally publishedYes

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HIV-1
Drug Users
Amino Acids
HIV
Proteins

Keywords

  • Drug users
  • Human immunodeficiency virus type 1
  • Tetrapeptide on tip of the V3 loop

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)

Cite this

@article{f5ad9d5580ee4c3f933066febd5622d4,
title = "Variation trend of the tetrapeptide on the tip of V3 loop of 62 HIV-1 strains isolated in idu of Yunnan from 1990 to 1997",
abstract = "Objective To investigate the variation trend of the amino acid and the corresponding nucleotide sequences of the tetrapeptide on the tip of the V3 loop of HIV-1 strains from intravenous drug users (IDUs) in Yunnan as time goes by. Methods According to the nucleotide sequences of the C2-V3 region of 62 HIV-1 strains isolated from intravenous drug users (IDUs) of Yunnan from 1990 to 1997, the nucleotide sequences of the tetrapeptide on the tip of the V3 loop of HIV-1 envelope protein were analysed. The variation trends with time were discussed. Results The tetrapeptides on the tip of the V3 loop of 62 Yunnan HIV-1 strains showed different amino acid variation with the major one at the fourth amino acid. Moreover, the variation tend to be in a similar pattern. Among the 62 isolated strains, 46 (74.2{\%} ) showed the GPGR tetrapeptide motif, 10 (16.1 {\%}) GPER motif, 4 (6.4{\%}) GPGK motif and 2 (3.3{\%}) GPER motif respectively. The variation at corresponding nucleotide sequence of the tetrapeptide motif was A→G. Conclusion In the period of 1990-1997, the tetrapeptides on the tip of the V3 loop of the HIV-1 strains from infected IDUs people in Yunnan are similar, and the results conform to the GPGR motif pattern of the international B subtype HIV-1SF2 strain.",
keywords = "Drug users, Human immunodeficiency virus type 1, Tetrapeptide on tip of the V3 loop",
author = "Hong Wu and Bin Wang and Rong Fang",
year = "2000",
month = "9",
language = "English (US)",
volume = "20",
pages = "462--464",
journal = "Chinese Journal of Microbiology and Immunology",
issn = "0254-5101",
publisher = "Society of Microbiology and Immunology",
number = "5",

}

TY - JOUR

T1 - Variation trend of the tetrapeptide on the tip of V3 loop of 62 HIV-1 strains isolated in idu of Yunnan from 1990 to 1997

AU - Wu, Hong

AU - Wang, Bin

AU - Fang, Rong

PY - 2000/9

Y1 - 2000/9

N2 - Objective To investigate the variation trend of the amino acid and the corresponding nucleotide sequences of the tetrapeptide on the tip of the V3 loop of HIV-1 strains from intravenous drug users (IDUs) in Yunnan as time goes by. Methods According to the nucleotide sequences of the C2-V3 region of 62 HIV-1 strains isolated from intravenous drug users (IDUs) of Yunnan from 1990 to 1997, the nucleotide sequences of the tetrapeptide on the tip of the V3 loop of HIV-1 envelope protein were analysed. The variation trends with time were discussed. Results The tetrapeptides on the tip of the V3 loop of 62 Yunnan HIV-1 strains showed different amino acid variation with the major one at the fourth amino acid. Moreover, the variation tend to be in a similar pattern. Among the 62 isolated strains, 46 (74.2% ) showed the GPGR tetrapeptide motif, 10 (16.1 %) GPER motif, 4 (6.4%) GPGK motif and 2 (3.3%) GPER motif respectively. The variation at corresponding nucleotide sequence of the tetrapeptide motif was A→G. Conclusion In the period of 1990-1997, the tetrapeptides on the tip of the V3 loop of the HIV-1 strains from infected IDUs people in Yunnan are similar, and the results conform to the GPGR motif pattern of the international B subtype HIV-1SF2 strain.

AB - Objective To investigate the variation trend of the amino acid and the corresponding nucleotide sequences of the tetrapeptide on the tip of the V3 loop of HIV-1 strains from intravenous drug users (IDUs) in Yunnan as time goes by. Methods According to the nucleotide sequences of the C2-V3 region of 62 HIV-1 strains isolated from intravenous drug users (IDUs) of Yunnan from 1990 to 1997, the nucleotide sequences of the tetrapeptide on the tip of the V3 loop of HIV-1 envelope protein were analysed. The variation trends with time were discussed. Results The tetrapeptides on the tip of the V3 loop of 62 Yunnan HIV-1 strains showed different amino acid variation with the major one at the fourth amino acid. Moreover, the variation tend to be in a similar pattern. Among the 62 isolated strains, 46 (74.2% ) showed the GPGR tetrapeptide motif, 10 (16.1 %) GPER motif, 4 (6.4%) GPGK motif and 2 (3.3%) GPER motif respectively. The variation at corresponding nucleotide sequence of the tetrapeptide motif was A→G. Conclusion In the period of 1990-1997, the tetrapeptides on the tip of the V3 loop of the HIV-1 strains from infected IDUs people in Yunnan are similar, and the results conform to the GPGR motif pattern of the international B subtype HIV-1SF2 strain.

KW - Drug users

KW - Human immunodeficiency virus type 1

KW - Tetrapeptide on tip of the V3 loop

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