TY - JOUR
T1 - Variations in cervical IL-10 and IL-8 concentrations throughout gestation in normal pregnancies
AU - Mondestin-Sorrentino, Myriam
AU - Smulian, John C.
AU - Vintzileos, Anthony M.
AU - Sorrentino, David
AU - Ananth, Cande V.
AU - Sharma, Surendra
AU - Hanna, Nazeeh N.
PY - 2007/6
Y1 - 2007/6
N2 - Problem: Data regarding cervical interleukin 18 (IL-8) and IL-10 concentrations during pregnancy is limited. Methodod study: This was across sectional study of healthy pregnant women. Specimens were collected from the cervical os secretions. IL-8 and IL-10 levels were measured by using enzyme-linked immunosorbent assay. Median (range) cytokine concentrations were derived for each trimester and compared across trimesters. The relationship between gestational age and cytokine levels was assessed by regression analysis. The mean of the ratios of IL-8 to IL-10 was compared in each trimester using anova. Results: The median (range) IL-8 concentrations in cervical secretions were in pg/mL: 1562 (1210-4100), 2460 (1047-4688), 3660 (1451-4748) (P < 0.0021); the median (range) IL-10 concentrations in cervical secretions were in pg/mL: 38.3 (6.8-227.9), 10.9 (0-263.3), 9.5 (0-35.6); the mean IL10/IL-8 × 100 (+/-standard deviation) concentrations were: 3.33 ± 0.65, 1.47 ± 0.41, 0.38 ± 0.52 (P = 0.0035) during the first, second and third trimesters, respectively. Conclusion: The patterns of cervical IL-8 concentration is inversely related to gestational age, and the ratio of IL-10/IL-8 decreases with advancing gestation.
AB - Problem: Data regarding cervical interleukin 18 (IL-8) and IL-10 concentrations during pregnancy is limited. Methodod study: This was across sectional study of healthy pregnant women. Specimens were collected from the cervical os secretions. IL-8 and IL-10 levels were measured by using enzyme-linked immunosorbent assay. Median (range) cytokine concentrations were derived for each trimester and compared across trimesters. The relationship between gestational age and cytokine levels was assessed by regression analysis. The mean of the ratios of IL-8 to IL-10 was compared in each trimester using anova. Results: The median (range) IL-8 concentrations in cervical secretions were in pg/mL: 1562 (1210-4100), 2460 (1047-4688), 3660 (1451-4748) (P < 0.0021); the median (range) IL-10 concentrations in cervical secretions were in pg/mL: 38.3 (6.8-227.9), 10.9 (0-263.3), 9.5 (0-35.6); the mean IL10/IL-8 × 100 (+/-standard deviation) concentrations were: 3.33 ± 0.65, 1.47 ± 0.41, 0.38 ± 0.52 (P = 0.0035) during the first, second and third trimesters, respectively. Conclusion: The patterns of cervical IL-8 concentration is inversely related to gestational age, and the ratio of IL-10/IL-8 decreases with advancing gestation.
KW - Cervical IL-8
KW - CervicalIL-10
KW - Gestational age
KW - IL10/IL8 ratio
KW - Pregnancy
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U2 - 10.1111/j.1600-0897.2007.00468.x
DO - 10.1111/j.1600-0897.2007.00468.x
M3 - Article
C2 - 17501766
AN - SCOPUS:34248642853
SN - 1046-7408
VL - 57
SP - 482
EP - 487
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
IS - 6
ER -