Vascular biology of hydrogen sulfide

    Research output: Contribution to journalArticle

    35 Citations (Scopus)

    Abstract

    Hydrogen sulfide (H2S) is a ubiquitous signaling molecule with important functions in many mammalian organs and systems. Observations in the 1990s ascribed physiological actions to H2Sinthe nervous system, proposing that this gasotransmitter acts as a neuromodulator. Soon after that, the vasodilating properties of H2S were demonstrated. In the past decade, H2S was shown to exert a multitude of physiological effects in the vessel wall. H2S is produced by vascular cells and exhibits antioxidant, antiapoptotic, anti-inflammatory, and vasoactive properties. In this concise review, we have focused on the impact of H2S on vascular structure and function with an emphasis on angiogenesis, vascular tone, vascular permeability and atherosclerosis. H2S reduces arterial blood pressure, limits atheromatous plaque formation, and promotes vascularization of ischemic tissues. Although the beneficial properties of H2S are well established, mechanistic insights into the molecular pathways implicated in disease prevention and treatment remain largely unexplored. Unraveling the targets and downstream effectors of H2S in the vessel wall in the context of disease will aid in translation of preclinical observations. In addition, acute regulation of H2S production is still poorly understood and additional work delineating the pathways regulating the enzymes that produce H2S will allow pharmacological manipulation of this pathway. As the field continues to grow, we expect that H2 S-related compounds will find their way into clinical trials for diseases affecting the blood vessels.

    Original languageEnglish (US)
    Pages (from-to)C537-C549
    JournalAmerican Journal of Physiology - Cell Physiology
    Volume312
    Issue number5
    DOIs
    StatePublished - May 1 2017

    Fingerprint

    Hydrogen Sulfide
    Blood Vessels
    Gasotransmitters
    Capillary Permeability
    Atherosclerotic Plaques
    Nervous System
    Neurotransmitter Agents
    Atherosclerosis
    Arterial Pressure
    Anti-Inflammatory Agents
    Antioxidants
    Clinical Trials
    Pharmacology
    Enzymes

    Keywords

    • Blood vessels
    • Endothelium
    • Hydrogen sulfide
    • Signaling
    • Vascular smooth muscle

    ASJC Scopus subject areas

    • Physiology
    • Cell Biology

    Cite this

    Vascular biology of hydrogen sulfide. / Kanagy, Nancy L.; Szabo, Csaba; Papapetropoulos, Andreas.

    In: American Journal of Physiology - Cell Physiology, Vol. 312, No. 5, 01.05.2017, p. C537-C549.

    Research output: Contribution to journalArticle

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