Vascular reactivity in preeclampsia

Y. Vedernikov, George Saade, R. E. Garfield

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

It has long been known that vascular reactivity is altered in preeclamptic patients compared with normal pregnant women. This change even occurs weeks earlier than any clinical manifestation of the disease. Many investigators believe that the conditions for the development of preeclampsia are set as early as the first trimester. These changes in vascular reactivity appear to be independent of the blood pressure because they also occur in chronic hypertensive women destined to have preeclampsia. This review focuses on these changes in vascular reactivity reported in preeclampsia. Increased reactivity of the blood vessels in preeclampsia has been described in most, but not all, studies. The cause for the differences in reactivity between vessels from preeclamptic and normal pregnant women is not known. However, it cannot be attributed solely and with certainty to abnormalities in endothelium-dependent relaxation or the nitric oxide system because the study results published to date remain contradictory. In addition to functional differences, vessels from normal pregnant and preeclamptic women show distinct mechanical properties.

Original languageEnglish (US)
Pages (from-to)34-44
Number of pages11
JournalSeminars in Perinatology
Volume23
Issue number1
StatePublished - 1999

Fingerprint

Pre-Eclampsia
Blood Vessels
Pregnant Women
First Pregnancy Trimester
Endothelium
Nitric Oxide
Research Personnel
Blood Pressure

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Vedernikov, Y., Saade, G., & Garfield, R. E. (1999). Vascular reactivity in preeclampsia. Seminars in Perinatology, 23(1), 34-44.

Vascular reactivity in preeclampsia. / Vedernikov, Y.; Saade, George; Garfield, R. E.

In: Seminars in Perinatology, Vol. 23, No. 1, 1999, p. 34-44.

Research output: Contribution to journalArticle

Vedernikov, Y, Saade, G & Garfield, RE 1999, 'Vascular reactivity in preeclampsia', Seminars in Perinatology, vol. 23, no. 1, pp. 34-44.
Vedernikov Y, Saade G, Garfield RE. Vascular reactivity in preeclampsia. Seminars in Perinatology. 1999;23(1):34-44.
Vedernikov, Y. ; Saade, George ; Garfield, R. E. / Vascular reactivity in preeclampsia. In: Seminars in Perinatology. 1999 ; Vol. 23, No. 1. pp. 34-44.
@article{7021c5e576544c04b997736017ac714a,
title = "Vascular reactivity in preeclampsia",
abstract = "It has long been known that vascular reactivity is altered in preeclamptic patients compared with normal pregnant women. This change even occurs weeks earlier than any clinical manifestation of the disease. Many investigators believe that the conditions for the development of preeclampsia are set as early as the first trimester. These changes in vascular reactivity appear to be independent of the blood pressure because they also occur in chronic hypertensive women destined to have preeclampsia. This review focuses on these changes in vascular reactivity reported in preeclampsia. Increased reactivity of the blood vessels in preeclampsia has been described in most, but not all, studies. The cause for the differences in reactivity between vessels from preeclamptic and normal pregnant women is not known. However, it cannot be attributed solely and with certainty to abnormalities in endothelium-dependent relaxation or the nitric oxide system because the study results published to date remain contradictory. In addition to functional differences, vessels from normal pregnant and preeclamptic women show distinct mechanical properties.",
author = "Y. Vedernikov and George Saade and Garfield, {R. E.}",
year = "1999",
language = "English (US)",
volume = "23",
pages = "34--44",
journal = "Seminars in Perinatology",
issn = "0146-0005",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Vascular reactivity in preeclampsia

AU - Vedernikov, Y.

AU - Saade, George

AU - Garfield, R. E.

PY - 1999

Y1 - 1999

N2 - It has long been known that vascular reactivity is altered in preeclamptic patients compared with normal pregnant women. This change even occurs weeks earlier than any clinical manifestation of the disease. Many investigators believe that the conditions for the development of preeclampsia are set as early as the first trimester. These changes in vascular reactivity appear to be independent of the blood pressure because they also occur in chronic hypertensive women destined to have preeclampsia. This review focuses on these changes in vascular reactivity reported in preeclampsia. Increased reactivity of the blood vessels in preeclampsia has been described in most, but not all, studies. The cause for the differences in reactivity between vessels from preeclamptic and normal pregnant women is not known. However, it cannot be attributed solely and with certainty to abnormalities in endothelium-dependent relaxation or the nitric oxide system because the study results published to date remain contradictory. In addition to functional differences, vessels from normal pregnant and preeclamptic women show distinct mechanical properties.

AB - It has long been known that vascular reactivity is altered in preeclamptic patients compared with normal pregnant women. This change even occurs weeks earlier than any clinical manifestation of the disease. Many investigators believe that the conditions for the development of preeclampsia are set as early as the first trimester. These changes in vascular reactivity appear to be independent of the blood pressure because they also occur in chronic hypertensive women destined to have preeclampsia. This review focuses on these changes in vascular reactivity reported in preeclampsia. Increased reactivity of the blood vessels in preeclampsia has been described in most, but not all, studies. The cause for the differences in reactivity between vessels from preeclamptic and normal pregnant women is not known. However, it cannot be attributed solely and with certainty to abnormalities in endothelium-dependent relaxation or the nitric oxide system because the study results published to date remain contradictory. In addition to functional differences, vessels from normal pregnant and preeclamptic women show distinct mechanical properties.

UR - http://www.scopus.com/inward/record.url?scp=0032970733&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032970733&partnerID=8YFLogxK

M3 - Article

VL - 23

SP - 34

EP - 44

JO - Seminars in Perinatology

JF - Seminars in Perinatology

SN - 0146-0005

IS - 1

ER -