Vasoactive intestinal polypeptide (VIP) immunoreactivity in the ependymal cells of the rat spinal cord

K. Chung, W. T. Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Vasoactive intestinal polypeptide (VIP) was demonstrated immunohistochemically in the entire ependymal and subependymal cells in all levels (cervical: C, thoracic: T, lumbar: L and sacral: S) of normal adult rat spinal cord. The VIP-immunoreactive basal processes from the apical ependymal cells coursed dorsally or ventrally along the median plane and reached the pia mater of the dorsal and ventral median septa. Many VIP-immunoreactive basal processes terminated on the blood vessels in the neuropil around the central canal. A few microvilli of the ependymal cells that project into the central canal also demonstrated intense VIP immunoreactivity. These observations suggest that ependymal cells may be involved in the modulation of VIP levels in the cerebrospinal fluid and regulation of vascular tone of the blood vessels in the spinal cord.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalNeuroscience Letters
Volume95
Issue number1-3
DOIs
StatePublished - Dec 19 1988

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Vasoactive Intestinal Peptide
Spinal Cord
Blood Vessels
Pia Mater
Neuropil
Microvilli
Cerebrospinal Fluid
Thorax

Keywords

  • Central canal
  • Glia
  • Peptide
  • Rat
  • Spinal cord
  • Ultrastructure

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Vasoactive intestinal polypeptide (VIP) immunoreactivity in the ependymal cells of the rat spinal cord. / Chung, K.; Lee, W. T.

In: Neuroscience Letters, Vol. 95, No. 1-3, 19.12.1988, p. 1-6.

Research output: Contribution to journalArticle

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