Vasoactive intestinal polypeptide (VIP) immunoreactivity in the ependymal cells of the rat spinal cord

K. Chung; W. T. Lee

doi:10.1016/0304-3940(88)90622-2

Vasoactive intestinal polypeptide (VIP) immunoreactivity in the ependymal cells of the rat spinal cord

K. Chung, W. T. Lee

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Vasoactive intestinal polypeptide (VIP) was demonstrated immunohistochemically in the entire ependymal and subependymal cells in all levels (cervical: C, thoracic: T, lumbar: L and sacral: S) of normal adult rat spinal cord. The VIP-immunoreactive basal processes from the apical ependymal cells coursed dorsally or ventrally along the median plane and reached the pia mater of the dorsal and ventral median septa. Many VIP-immunoreactive basal processes terminated on the blood vessels in the neuropil around the central canal. A few microvilli of the ependymal cells that project into the central canal also demonstrated intense VIP immunoreactivity. These observations suggest that ependymal cells may be involved in the modulation of VIP levels in the cerebrospinal fluid and regulation of vascular tone of the blood vessels in the spinal cord.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Neuroscience Letters
Volume	95
Issue number	1-3
DOIs	https://doi.org/10.1016/0304-3940(88)90622-2
State	Published - Dec 19 1988

Keywords

Central canal
Glia
Peptide
Rat
Spinal cord
Ultrastructure

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(88)90622-2

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@article{6bff46e7d5094676bd7e3683916a2a33,

title = "Vasoactive intestinal polypeptide (VIP) immunoreactivity in the ependymal cells of the rat spinal cord",

abstract = "Vasoactive intestinal polypeptide (VIP) was demonstrated immunohistochemically in the entire ependymal and subependymal cells in all levels (cervical: C, thoracic: T, lumbar: L and sacral: S) of normal adult rat spinal cord. The VIP-immunoreactive basal processes from the apical ependymal cells coursed dorsally or ventrally along the median plane and reached the pia mater of the dorsal and ventral median septa. Many VIP-immunoreactive basal processes terminated on the blood vessels in the neuropil around the central canal. A few microvilli of the ependymal cells that project into the central canal also demonstrated intense VIP immunoreactivity. These observations suggest that ependymal cells may be involved in the modulation of VIP levels in the cerebrospinal fluid and regulation of vascular tone of the blood vessels in the spinal cord.",

keywords = "Central canal, Glia, Peptide, Rat, Spinal cord, Ultrastructure",

author = "K. Chung and Lee, {W. T.}",

note = "Funding Information: This work was supported by National Institute of Health Grant NSl1255, the Muscular Dystrophy Association and the Florence and Marie Hall Endowment for Excellence in Medical Education. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1988",

month = dec,

day = "19",

doi = "10.1016/0304-3940(88)90622-2",

language = "English (US)",

volume = "95",

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T1 - Vasoactive intestinal polypeptide (VIP) immunoreactivity in the ependymal cells of the rat spinal cord

AU - Chung, K.

AU - Lee, W. T.

N1 - Funding Information: This work was supported by National Institute of Health Grant NSl1255, the Muscular Dystrophy Association and the Florence and Marie Hall Endowment for Excellence in Medical Education. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1988/12/19

Y1 - 1988/12/19

N2 - Vasoactive intestinal polypeptide (VIP) was demonstrated immunohistochemically in the entire ependymal and subependymal cells in all levels (cervical: C, thoracic: T, lumbar: L and sacral: S) of normal adult rat spinal cord. The VIP-immunoreactive basal processes from the apical ependymal cells coursed dorsally or ventrally along the median plane and reached the pia mater of the dorsal and ventral median septa. Many VIP-immunoreactive basal processes terminated on the blood vessels in the neuropil around the central canal. A few microvilli of the ependymal cells that project into the central canal also demonstrated intense VIP immunoreactivity. These observations suggest that ependymal cells may be involved in the modulation of VIP levels in the cerebrospinal fluid and regulation of vascular tone of the blood vessels in the spinal cord.

AB - Vasoactive intestinal polypeptide (VIP) was demonstrated immunohistochemically in the entire ependymal and subependymal cells in all levels (cervical: C, thoracic: T, lumbar: L and sacral: S) of normal adult rat spinal cord. The VIP-immunoreactive basal processes from the apical ependymal cells coursed dorsally or ventrally along the median plane and reached the pia mater of the dorsal and ventral median septa. Many VIP-immunoreactive basal processes terminated on the blood vessels in the neuropil around the central canal. A few microvilli of the ependymal cells that project into the central canal also demonstrated intense VIP immunoreactivity. These observations suggest that ependymal cells may be involved in the modulation of VIP levels in the cerebrospinal fluid and regulation of vascular tone of the blood vessels in the spinal cord.

KW - Central canal

KW - Glia

KW - Peptide

KW - Rat

KW - Spinal cord

KW - Ultrastructure

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U2 - 10.1016/0304-3940(88)90622-2

DO - 10.1016/0304-3940(88)90622-2

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AN - SCOPUS:0023797065

SN - 0304-3940

VL - 95

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-3

ER -

Vasoactive intestinal polypeptide (VIP) immunoreactivity in the ependymal cells of the rat spinal cord

Abstract

Keywords

ASJC Scopus subject areas

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