TY - JOUR
T1 - Vector surveillance during a major chikungunya outbreak in northwestern São Paulo state, Brazil
AU - Banho, Cecília Artico
AU - Parra, Maisa Carla Pereira
AU - Nascimento, Olivia Borghi
AU - Magnani, Gabriel Pires
AU - Ferreira, Maria Vitoria Moraes
AU - Lemos, Ana Paula
AU - Lourenço, Karine Lima
AU - de Carvalho Marques, Beatriz
AU - Brancini, Marini Lino
AU - Sacchetto, Livia
AU - Negri, Andreia Francesli
AU - Menezes, Regiane Maria Tironi de
AU - de Deus, Juliana Telles
AU - Estofolete, Cassia Fernanda
AU - Júnior, João Pessoa Araujo
AU - Vasilakis, Nikos
AU - Nogueira, Maurício Lacerda
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/12
Y1 - 2025/12
N2 - Brazil constitutes a hotspot for arbovirus emergence, posing persistent public health challenges. In São José do Rio Preto (SJdRP), dengue has historically predominated, whereas only 62 chikungunya virus (CHIKV) cases were reported between 2015 and 2023, suggesting cryptic circulation. However, from 2024 onwards, CHIKV notifications began to increase across São Paulo State. Because arboviral febrile illnesses frequently overlap clinically, early detection necessitates robust surveillance systems. To address this, mosquito collections were conducted over 15 months in SJdRP and screened for CHIKV RNA. Positive specimens were further analyzed through virus isolation and whole-genome sequencing. Overall, 5.6% of specimens tested positive, with prevalence rising from December 2023 and peaking in May 2024, coinciding with human cases. Phylogenetic reconstruction indicated multiple introductions, primarily from southeastern Brazil, driving viral establishment. These events likely facilitated transmission within a dense, susceptible vector population, contributing to extensive spread and culminating in a major CHIKV outbreak in northwestern São Paulo.
AB - Brazil constitutes a hotspot for arbovirus emergence, posing persistent public health challenges. In São José do Rio Preto (SJdRP), dengue has historically predominated, whereas only 62 chikungunya virus (CHIKV) cases were reported between 2015 and 2023, suggesting cryptic circulation. However, from 2024 onwards, CHIKV notifications began to increase across São Paulo State. Because arboviral febrile illnesses frequently overlap clinically, early detection necessitates robust surveillance systems. To address this, mosquito collections were conducted over 15 months in SJdRP and screened for CHIKV RNA. Positive specimens were further analyzed through virus isolation and whole-genome sequencing. Overall, 5.6% of specimens tested positive, with prevalence rising from December 2023 and peaking in May 2024, coinciding with human cases. Phylogenetic reconstruction indicated multiple introductions, primarily from southeastern Brazil, driving viral establishment. These events likely facilitated transmission within a dense, susceptible vector population, contributing to extensive spread and culminating in a major CHIKV outbreak in northwestern São Paulo.
UR - https://www.scopus.com/pages/publications/105022250541
UR - https://www.scopus.com/pages/publications/105022250541#tab=citedBy
U2 - 10.1038/s44298-025-00161-6
DO - 10.1038/s44298-025-00161-6
M3 - Article
C2 - 41238892
AN - SCOPUS:105022250541
SN - 2948-1767
VL - 3
JO - NPJ Viruses
JF - NPJ Viruses
IS - 1
M1 - 78
ER -