Venezuelan equine encephalitis virus infection of cotton rats

Anne Sophie Carrara, Lark L. Coffey, Patricia Aguilar, Abelardo C. Moncayo, Amelia P A Travassos Da Rosa, Marcio R T Nunes, Robert B. Tesh, Scott Weaver

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Abstract

Venezuelan equine encephalitis virus (VEEV) is an emerging pathogen of equids and humans, but infection of its rodent reservoir hosts has received little study. To determine whether responses to infection vary among geographic populations, we inoculated 3 populations of cotton rats with 2 enzootic VEEV strains (Co97-0054 [enzootic ID subtype] and 68U201 [enzootic IE subtype]). The 3 populations were offspring from wild-caught cotton rats collected in a VEE-enzootic area of south Florida, USA; wild-caught cotton rats from a non-VEE-enzootic area of Texas, USA; and commercially available (Harlan) colony-reared cotton rats from a non-VEE-enzootic region. Although each population had similar early viremia titers, no detectable disease developed in the VEE-sympatric Florida animals, but severe disease and death affected the Texas and Harlan animals. Our findings suggest that the geographic origins of cotton rats are important determinants of the outcome of VEE infection and reservoir potential of these rodents.

Original languageEnglish (US)
Pages (from-to)1158-1165
Number of pages8
JournalEmerging Infectious Diseases
Volume13
Issue number8
StatePublished - Aug 2007

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Venezuelan Equine Encephalitis Viruses
Sigmodontinae
Virus Diseases
Population
Rodentia
Infection
Animal Diseases
Viremia
Infectious Encephalitis

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Carrara, A. S., Coffey, L. L., Aguilar, P., Moncayo, A. C., Travassos Da Rosa, A. P. A., Nunes, M. R. T., ... Weaver, S. (2007). Venezuelan equine encephalitis virus infection of cotton rats. Emerging Infectious Diseases, 13(8), 1158-1165.

Venezuelan equine encephalitis virus infection of cotton rats. / Carrara, Anne Sophie; Coffey, Lark L.; Aguilar, Patricia; Moncayo, Abelardo C.; Travassos Da Rosa, Amelia P A; Nunes, Marcio R T; Tesh, Robert B.; Weaver, Scott.

In: Emerging Infectious Diseases, Vol. 13, No. 8, 08.2007, p. 1158-1165.

Research output: Contribution to journalArticle

Carrara, AS, Coffey, LL, Aguilar, P, Moncayo, AC, Travassos Da Rosa, APA, Nunes, MRT, Tesh, RB & Weaver, S 2007, 'Venezuelan equine encephalitis virus infection of cotton rats', Emerging Infectious Diseases, vol. 13, no. 8, pp. 1158-1165.
Carrara AS, Coffey LL, Aguilar P, Moncayo AC, Travassos Da Rosa APA, Nunes MRT et al. Venezuelan equine encephalitis virus infection of cotton rats. Emerging Infectious Diseases. 2007 Aug;13(8):1158-1165.
Carrara, Anne Sophie ; Coffey, Lark L. ; Aguilar, Patricia ; Moncayo, Abelardo C. ; Travassos Da Rosa, Amelia P A ; Nunes, Marcio R T ; Tesh, Robert B. ; Weaver, Scott. / Venezuelan equine encephalitis virus infection of cotton rats. In: Emerging Infectious Diseases. 2007 ; Vol. 13, No. 8. pp. 1158-1165.
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