Venezuelan equine encephalomyelitis virus structure and its divergence from Old World alphaviruses

A. Paredes, K. Alwell-Warda, Scott Weaver, W. Chiu, Stanley Watowich

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Although alphaviruses have been extensively studied as model systems for the structural organization of enveloped viruses, no structures exist for the phylogenetically distinct eastern equine encephalomyelitis (EEE)-Venezuelan equine encephalomyelitis (VEE) lineage of New World alphaviruses. Here we report the 25-Å structure of VEE virus, obtained from electron cryomicroscopy and image reconstruction. The envelope spike glycoproteins of VEE virus have a T=4 icosahedral arrangement, similar to that observed in Old World Sindbis, Semliki Forest, and Ross River alphaviruses. However, VEE virus has pronounced differences in its nucleocapsid structure relative to nucleocapsid structures repeatedly observed in Old World alphaviruses.

Original languageEnglish (US)
Pages (from-to)9532-9537
Number of pages6
JournalJournal of Virology
Volume75
Issue number19
DOIs
StatePublished - 2001

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Venezuelan Equine Encephalitis Viruses
Venezuelan equine encephalitis virus
viral morphology
Alphavirus
Viral Structures
Nucleocapsid
nucleocapsid
Eastern Equine Encephalomyelitis
Venezuelan equine encephalomyelitis
Eastern equine encephalomyelitis
Venezuelan Equine Encephalomyelitides
Cryoelectron Microscopy
Computer-Assisted Image Processing
Structural Models
Rivers
glycoproteins
Glycoproteins
inflorescences
viruses
rivers

ASJC Scopus subject areas

  • Immunology

Cite this

Venezuelan equine encephalomyelitis virus structure and its divergence from Old World alphaviruses. / Paredes, A.; Alwell-Warda, K.; Weaver, Scott; Chiu, W.; Watowich, Stanley.

In: Journal of Virology, Vol. 75, No. 19, 2001, p. 9532-9537.

Research output: Contribution to journalArticle

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