TY - JOUR
T1 - Venezuelan haemorrhagic fever
AU - Salas, R.
AU - Pacheco, M. E.
AU - Ramos, B.
AU - Taibo, M. E.
AU - Jaimes, E.
AU - Vasquez, C.
AU - Querales, J.
AU - de Manzione, N.
AU - Godoy, O.
AU - Betancourt, A.
AU - Araoz, F.
AU - Bruzual, R.
AU - Garcia, J.
AU - Tesh, R. B.
AU - Rico-Hesse, R.
AU - Shops, R. E.
N1 - Funding Information:
We thank Mr Juan Carlos Navarro, Mr Humberto Montanez, and Mr Jose Manuel Rios, Malariology Service, Ministry of Health and Social Assistance, for help in collecting some of the human sera and rodent samples and Ms Iris Rojas, Ms Celia Rivas, and Ms Magdalia Rojas, National Institute of Hygiene "Rafael Rangel" for their technical assistance. We also wish to acknowledge the help of all the medical and paramedical personnel of the Miguel Oraa Hospital, in the care of the haemorrhagic fever patients. Our work was supported in part by the Pan American Health Organization (travel fellowship to R. S.), the National Institutes of Health (grant AI-10984 to R. B. T.), and the US Army Medical Research and Development Command (DAMD 17-90-Z-0020 to R. E. S.).
PY - 1991/10/26
Y1 - 1991/10/26
N2 - An outbreak of severe haemorrhagic illness began in the municipality of Guanarito, Portuguesa State, Venezuela, in September, 1989. Subsequent detailed study of 15 cases confirmed the presence of a new viral disease, designated Venezuelan haemorrhagic fever. Characteristic features are fever, toxicity, headache, arthralgia, diarrhoea, conjunctivitis, pharyngitis, leucopenia, thrombocytopenia, and haemorrhagic manifestations. Other features include facial oedema, cervical lymphadenopathy, nausea/vomiting, cough, chest or abdominal pain, and convulsions. The patients ranged in age from 6 to 54 years; all were residents of rural areas in central Venezuela, and 9 died. Infection with Guanarito virus, a newly recognised arenavirus, was shown by direct culture or by serological confirmation in all cases. Epidemiological studies suggest that the disease is endemic in some rural areas of central Venezuela and that it is rodent-borne. Venezuelan haemorrhagic fever has many similarities to Lassa fever and to the arenavirus haemorrhagic fevers that occur in Argentina and Bolivia.
AB - An outbreak of severe haemorrhagic illness began in the municipality of Guanarito, Portuguesa State, Venezuela, in September, 1989. Subsequent detailed study of 15 cases confirmed the presence of a new viral disease, designated Venezuelan haemorrhagic fever. Characteristic features are fever, toxicity, headache, arthralgia, diarrhoea, conjunctivitis, pharyngitis, leucopenia, thrombocytopenia, and haemorrhagic manifestations. Other features include facial oedema, cervical lymphadenopathy, nausea/vomiting, cough, chest or abdominal pain, and convulsions. The patients ranged in age from 6 to 54 years; all were residents of rural areas in central Venezuela, and 9 died. Infection with Guanarito virus, a newly recognised arenavirus, was shown by direct culture or by serological confirmation in all cases. Epidemiological studies suggest that the disease is endemic in some rural areas of central Venezuela and that it is rodent-borne. Venezuelan haemorrhagic fever has many similarities to Lassa fever and to the arenavirus haemorrhagic fevers that occur in Argentina and Bolivia.
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U2 - 10.1016/0140-6736(91)91899-6
DO - 10.1016/0140-6736(91)91899-6
M3 - Article
C2 - 1681354
AN - SCOPUS:0025997587
SN - 0140-6736
VL - 338
SP - 1033
EP - 1036
JO - The Lancet
JF - The Lancet
IS - 8774
ER -