Venezuelan haemorrhagic fever

R. Salas, M. E. Pacheco, B. Ramos, M. E. Taibo, E. Jaimes, C. Vasquez, J. Querales, N. de Manzione, O. Godoy, A. Betancourt, F. Araoz, R. Bruzual, J. Garcia, R. B. Tesh, R. Rico-Hesse, R. E. Shops

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

An outbreak of severe haemorrhagic illness began in the municipality of Guanarito, Portuguesa State, Venezuela, in September, 1989. Subsequent detailed study of 15 cases confirmed the presence of a new viral disease, designated Venezuelan haemorrhagic fever. Characteristic features are fever, toxicity, headache, arthralgia, diarrhoea, conjunctivitis, pharyngitis, leucopenia, thrombocytopenia, and haemorrhagic manifestations. Other features include facial oedema, cervical lymphadenopathy, nausea/vomiting, cough, chest or abdominal pain, and convulsions. The patients ranged in age from 6 to 54 years; all were residents of rural areas in central Venezuela, and 9 died. Infection with Guanarito virus, a newly recognised arenavirus, was shown by direct culture or by serological confirmation in all cases. Epidemiological studies suggest that the disease is endemic in some rural areas of central Venezuela and that it is rodent-borne. Venezuelan haemorrhagic fever has many similarities to Lassa fever and to the arenavirus haemorrhagic fevers that occur in Argentina and Bolivia.

Original languageEnglish (US)
Pages (from-to)1033-1036
Number of pages4
JournalThe Lancet
Volume338
Issue number8774
DOIs
StatePublished - Oct 26 1991
Externally publishedYes

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Venezuela
Fever
Arenavirus
New World Arenaviruses
Lassa Fever
Bolivia
Endemic Diseases
Conjunctivitis
Pharyngitis
Argentina
Leukopenia
Arthralgia
Virus Diseases
Chest Pain
Cough
Thrombocytopenia
Nausea
Abdominal Pain
Vomiting
Disease Outbreaks

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Salas, R., Pacheco, M. E., Ramos, B., Taibo, M. E., Jaimes, E., Vasquez, C., ... Shops, R. E. (1991). Venezuelan haemorrhagic fever. The Lancet, 338(8774), 1033-1036. https://doi.org/10.1016/0140-6736(91)91899-6

Venezuelan haemorrhagic fever. / Salas, R.; Pacheco, M. E.; Ramos, B.; Taibo, M. E.; Jaimes, E.; Vasquez, C.; Querales, J.; de Manzione, N.; Godoy, O.; Betancourt, A.; Araoz, F.; Bruzual, R.; Garcia, J.; Tesh, R. B.; Rico-Hesse, R.; Shops, R. E.

In: The Lancet, Vol. 338, No. 8774, 26.10.1991, p. 1033-1036.

Research output: Contribution to journalArticle

Salas, R, Pacheco, ME, Ramos, B, Taibo, ME, Jaimes, E, Vasquez, C, Querales, J, de Manzione, N, Godoy, O, Betancourt, A, Araoz, F, Bruzual, R, Garcia, J, Tesh, RB, Rico-Hesse, R & Shops, RE 1991, 'Venezuelan haemorrhagic fever', The Lancet, vol. 338, no. 8774, pp. 1033-1036. https://doi.org/10.1016/0140-6736(91)91899-6
Salas R, Pacheco ME, Ramos B, Taibo ME, Jaimes E, Vasquez C et al. Venezuelan haemorrhagic fever. The Lancet. 1991 Oct 26;338(8774):1033-1036. https://doi.org/10.1016/0140-6736(91)91899-6
Salas, R. ; Pacheco, M. E. ; Ramos, B. ; Taibo, M. E. ; Jaimes, E. ; Vasquez, C. ; Querales, J. ; de Manzione, N. ; Godoy, O. ; Betancourt, A. ; Araoz, F. ; Bruzual, R. ; Garcia, J. ; Tesh, R. B. ; Rico-Hesse, R. ; Shops, R. E. / Venezuelan haemorrhagic fever. In: The Lancet. 1991 ; Vol. 338, No. 8774. pp. 1033-1036.
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