Venous thromboembolism in patients with head and neck cancer after surgery

Leo Thai, Kate McCarn, William Stott, Tammara Watts, Mark K. Wax, Peter E. Andersen, Neil D. Gross

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background The purpose of this study was to report the incidence of venous thromboembolism (VTE) in patients with head and neck cancer after surgery. Methods This was a single-institution, retrospective cohort: 134 patients underwent resection and simultaneous microvascular reconstruction. The primary endpoint was identification of confirmed or suspicious VTE within 30 days of surgery. Results Two subjects (1.4%) with confirmed VTE (1 pulmonary embolism, 1 deep venous thrombosis) and 6 subjects (4.4%) with suspicious VTE (1 acute respiratory failure, 1 sudden cardiac arrest, and 4 cases of leg edema without imaging) were identified. The strongest predictors of possible VTE were prior VTE (p =.004; odds ratio [OR], 25.11; 95% confidence interval [CI], 1.13-556.40), red cell transfusion (p =.009; OR, 1.80; 95% CI, 1.16-2.80), high body mass index (p =.015, OR, 1.29, 95% CI, 1.05-1.58), and older age (p =.046; OR, 1.10; 95% CI, 1.00-1.19). Conclusion The incidence of VTE in patients with head and neck cancer after resection and microvascular reconstruction ranged from 1.4% to 5.8%.

Original languageEnglish (US)
Pages (from-to)4-9
Number of pages6
JournalHead and Neck
Volume35
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Fingerprint

Venous Thromboembolism
Head and Neck Neoplasms
Odds Ratio
Confidence Intervals
Sudden Cardiac Death
Incidence
Ambulatory Surgical Procedures
Pulmonary Embolism
Venous Thrombosis
Respiratory Insufficiency
Edema
Leg
Body Mass Index

Keywords

  • deep venous thrombosis
  • pulmonary embolism
  • squamous cell carcinoma
  • surgery
  • venous thromboembolism

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Thai, L., McCarn, K., Stott, W., Watts, T., Wax, M. K., Andersen, P. E., & Gross, N. D. (2013). Venous thromboembolism in patients with head and neck cancer after surgery. Head and Neck, 35(1), 4-9. https://doi.org/10.1002/hed.22920

Venous thromboembolism in patients with head and neck cancer after surgery. / Thai, Leo; McCarn, Kate; Stott, William; Watts, Tammara; Wax, Mark K.; Andersen, Peter E.; Gross, Neil D.

In: Head and Neck, Vol. 35, No. 1, 01.2013, p. 4-9.

Research output: Contribution to journalArticle

Thai, L, McCarn, K, Stott, W, Watts, T, Wax, MK, Andersen, PE & Gross, ND 2013, 'Venous thromboembolism in patients with head and neck cancer after surgery', Head and Neck, vol. 35, no. 1, pp. 4-9. https://doi.org/10.1002/hed.22920
Thai L, McCarn K, Stott W, Watts T, Wax MK, Andersen PE et al. Venous thromboembolism in patients with head and neck cancer after surgery. Head and Neck. 2013 Jan;35(1):4-9. https://doi.org/10.1002/hed.22920
Thai, Leo ; McCarn, Kate ; Stott, William ; Watts, Tammara ; Wax, Mark K. ; Andersen, Peter E. ; Gross, Neil D. / Venous thromboembolism in patients with head and neck cancer after surgery. In: Head and Neck. 2013 ; Vol. 35, No. 1. pp. 4-9.
@article{dc74b4ba38444e9aa26dc9f6545794bc,
title = "Venous thromboembolism in patients with head and neck cancer after surgery",
abstract = "Background The purpose of this study was to report the incidence of venous thromboembolism (VTE) in patients with head and neck cancer after surgery. Methods This was a single-institution, retrospective cohort: 134 patients underwent resection and simultaneous microvascular reconstruction. The primary endpoint was identification of confirmed or suspicious VTE within 30 days of surgery. Results Two subjects (1.4{\%}) with confirmed VTE (1 pulmonary embolism, 1 deep venous thrombosis) and 6 subjects (4.4{\%}) with suspicious VTE (1 acute respiratory failure, 1 sudden cardiac arrest, and 4 cases of leg edema without imaging) were identified. The strongest predictors of possible VTE were prior VTE (p =.004; odds ratio [OR], 25.11; 95{\%} confidence interval [CI], 1.13-556.40), red cell transfusion (p =.009; OR, 1.80; 95{\%} CI, 1.16-2.80), high body mass index (p =.015, OR, 1.29, 95{\%} CI, 1.05-1.58), and older age (p =.046; OR, 1.10; 95{\%} CI, 1.00-1.19). Conclusion The incidence of VTE in patients with head and neck cancer after resection and microvascular reconstruction ranged from 1.4{\%} to 5.8{\%}.",
keywords = "deep venous thrombosis, pulmonary embolism, squamous cell carcinoma, surgery, venous thromboembolism",
author = "Leo Thai and Kate McCarn and William Stott and Tammara Watts and Wax, {Mark K.} and Andersen, {Peter E.} and Gross, {Neil D.}",
year = "2013",
month = "1",
doi = "10.1002/hed.22920",
language = "English (US)",
volume = "35",
pages = "4--9",
journal = "Head and Neck Surgery",
issn = "1043-3074",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Venous thromboembolism in patients with head and neck cancer after surgery

AU - Thai, Leo

AU - McCarn, Kate

AU - Stott, William

AU - Watts, Tammara

AU - Wax, Mark K.

AU - Andersen, Peter E.

AU - Gross, Neil D.

PY - 2013/1

Y1 - 2013/1

N2 - Background The purpose of this study was to report the incidence of venous thromboembolism (VTE) in patients with head and neck cancer after surgery. Methods This was a single-institution, retrospective cohort: 134 patients underwent resection and simultaneous microvascular reconstruction. The primary endpoint was identification of confirmed or suspicious VTE within 30 days of surgery. Results Two subjects (1.4%) with confirmed VTE (1 pulmonary embolism, 1 deep venous thrombosis) and 6 subjects (4.4%) with suspicious VTE (1 acute respiratory failure, 1 sudden cardiac arrest, and 4 cases of leg edema without imaging) were identified. The strongest predictors of possible VTE were prior VTE (p =.004; odds ratio [OR], 25.11; 95% confidence interval [CI], 1.13-556.40), red cell transfusion (p =.009; OR, 1.80; 95% CI, 1.16-2.80), high body mass index (p =.015, OR, 1.29, 95% CI, 1.05-1.58), and older age (p =.046; OR, 1.10; 95% CI, 1.00-1.19). Conclusion The incidence of VTE in patients with head and neck cancer after resection and microvascular reconstruction ranged from 1.4% to 5.8%.

AB - Background The purpose of this study was to report the incidence of venous thromboembolism (VTE) in patients with head and neck cancer after surgery. Methods This was a single-institution, retrospective cohort: 134 patients underwent resection and simultaneous microvascular reconstruction. The primary endpoint was identification of confirmed or suspicious VTE within 30 days of surgery. Results Two subjects (1.4%) with confirmed VTE (1 pulmonary embolism, 1 deep venous thrombosis) and 6 subjects (4.4%) with suspicious VTE (1 acute respiratory failure, 1 sudden cardiac arrest, and 4 cases of leg edema without imaging) were identified. The strongest predictors of possible VTE were prior VTE (p =.004; odds ratio [OR], 25.11; 95% confidence interval [CI], 1.13-556.40), red cell transfusion (p =.009; OR, 1.80; 95% CI, 1.16-2.80), high body mass index (p =.015, OR, 1.29, 95% CI, 1.05-1.58), and older age (p =.046; OR, 1.10; 95% CI, 1.00-1.19). Conclusion The incidence of VTE in patients with head and neck cancer after resection and microvascular reconstruction ranged from 1.4% to 5.8%.

KW - deep venous thrombosis

KW - pulmonary embolism

KW - squamous cell carcinoma

KW - surgery

KW - venous thromboembolism

UR - http://www.scopus.com/inward/record.url?scp=84871247457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871247457&partnerID=8YFLogxK

U2 - 10.1002/hed.22920

DO - 10.1002/hed.22920

M3 - Article

C2 - 22302625

AN - SCOPUS:84871247457

VL - 35

SP - 4

EP - 9

JO - Head and Neck Surgery

JF - Head and Neck Surgery

SN - 1043-3074

IS - 1

ER -