Venovenous carbon dioxide removal in chronic obstructive pulmonary disease experience in one patient

Victor J. Cardenas, James E. Lynch, Reyhan Ates, Lucinda Miller, Joseph B. Zwischenberger

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States. Acute exacerbations of COPD account for up to 84% of the total economic cost of this disease. The altered mechanics of the COPD patient represent a unique challenge to the clinician instituting assisted ventilation in this population. We developed an alternative mode of limited extracorporeal support termed Venovenous carbon dioxide removal (VVCO 2R). We report our first case using VVCO 2R, a 42-year-old white woman with a history of COPD and asthma, who was a heavy smoker at the time of admission. We utilized a compact, low flow pediatric extracorporeal circuit interposed with a low resistance gas exchange device. Venovenous carbon dioxide removal allowed for a reduction in the patient's minute ventilation to 30% of baseline with improved arterial blood gases (ABGs), a reduction in peak airway pressures and improvement in her hyperinflation. Our experience demonstrates that this system can effectively remove CO 2 safely in a single cannula venous configuration while maintaining minimal anticoagulation. We believe this system could potentially be utilized in any medical or surgical intensive care unit.

Original languageEnglish (US)
Pages (from-to)420-422
Number of pages3
JournalASAIO Journal
Volume55
Issue number4
DOIs
StatePublished - Jul 2009

Fingerprint

Pulmonary diseases
Carbon Dioxide
Chronic Obstructive Pulmonary Disease
Carbon dioxide
Ventilation
Gases
Intensive care units
Pediatrics
Cost of Illness
Carbon Monoxide
Critical Care
Mechanics
Intensive Care Units
Cause of Death
Blood
Asthma
History
Economics
Pressure
Equipment and Supplies

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering
  • Medicine(all)

Cite this

Cardenas, V. J., Lynch, J. E., Ates, R., Miller, L., & Zwischenberger, J. B. (2009). Venovenous carbon dioxide removal in chronic obstructive pulmonary disease experience in one patient. ASAIO Journal, 55(4), 420-422. https://doi.org/10.1097/MAT.0b013e3181a7b55d

Venovenous carbon dioxide removal in chronic obstructive pulmonary disease experience in one patient. / Cardenas, Victor J.; Lynch, James E.; Ates, Reyhan; Miller, Lucinda; Zwischenberger, Joseph B.

In: ASAIO Journal, Vol. 55, No. 4, 07.2009, p. 420-422.

Research output: Contribution to journalArticle

Cardenas, VJ, Lynch, JE, Ates, R, Miller, L & Zwischenberger, JB 2009, 'Venovenous carbon dioxide removal in chronic obstructive pulmonary disease experience in one patient', ASAIO Journal, vol. 55, no. 4, pp. 420-422. https://doi.org/10.1097/MAT.0b013e3181a7b55d
Cardenas, Victor J. ; Lynch, James E. ; Ates, Reyhan ; Miller, Lucinda ; Zwischenberger, Joseph B. / Venovenous carbon dioxide removal in chronic obstructive pulmonary disease experience in one patient. In: ASAIO Journal. 2009 ; Vol. 55, No. 4. pp. 420-422.
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