Venovenous perfusion-induced systemic hyperthermia

Hemodynamics, blood flow, and thermal gradients

Roger A. Vertrees, Akhil Bidani, Donald J. Deyo, Weike Tao, Joseph B. Zwischenberger

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    Background. Thermal events during extracorporeal venovenous perfusion-induced systemic hyperthermia (VV-PISH) were studied and related to determination of whole-body and regional thermal isoeffect doses. Methods. Swine (n = 6, 77 ± 4.5 kg) were heated to a target temperature of 43°C for 120 minutes using VV-PISH. Colored microspheres were injected during pre-heat, heat induction, maintenance, cool down, and after decannulation. The esophageal, tympanic, rectal, pulmonary artery, bladder, bone marrow, kidney, brain, blood, lung, and airway temperatures were recorded continuously. The thermal dose, thermal exchange, metabolic heat production, heat loss to the environment, the change in body heat, and the thermal isoeffect dose were studied at 15-minute intervals. Results. VV-PISH increased heart rate and cardiac output and caused a redistribution of blood flow favoring the thoracoabdominal organs. Greatest thermal exchange occurred during the heating phase (total 2,162 ± 143 kJ), metabolic heat production contributed in all phases (274 ± 9 kJ), the greatest change in body heat occurred during heating (1,310 ± 309 kJ) with a total delivered thermal dose of 298 ± 21 kJ, and the total whole body thermal isoeffect dose at 100 ± 5 minutes. Conclusions. VV-PISH is feasible, is capable of transferring sufficient heat, causes a redistribution of blood flow favoring the thoracoabdominal organs, and facilitates calculation of whole-body and regional thermal isoeffect doses. (C) 2000 by The Society of Thoracic Surgeons.

    Original languageEnglish (US)
    Pages (from-to)644-652
    Number of pages9
    JournalAnnals of Thoracic Surgery
    Volume70
    Issue number2
    DOIs
    StatePublished - 2000

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    Induced Hyperthermia
    Perfusion
    Hot Temperature
    Hemodynamics
    Thermogenesis
    Heating
    Temperature
    Microspheres
    Cardiac Output
    Pulmonary Artery

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Surgery

    Cite this

    Venovenous perfusion-induced systemic hyperthermia : Hemodynamics, blood flow, and thermal gradients. / Vertrees, Roger A.; Bidani, Akhil; Deyo, Donald J.; Tao, Weike; Zwischenberger, Joseph B.

    In: Annals of Thoracic Surgery, Vol. 70, No. 2, 2000, p. 644-652.

    Research output: Contribution to journalArticle

    Vertrees, Roger A. ; Bidani, Akhil ; Deyo, Donald J. ; Tao, Weike ; Zwischenberger, Joseph B. / Venovenous perfusion-induced systemic hyperthermia : Hemodynamics, blood flow, and thermal gradients. In: Annals of Thoracic Surgery. 2000 ; Vol. 70, No. 2. pp. 644-652.
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    abstract = "Background. Thermal events during extracorporeal venovenous perfusion-induced systemic hyperthermia (VV-PISH) were studied and related to determination of whole-body and regional thermal isoeffect doses. Methods. Swine (n = 6, 77 ± 4.5 kg) were heated to a target temperature of 43°C for 120 minutes using VV-PISH. Colored microspheres were injected during pre-heat, heat induction, maintenance, cool down, and after decannulation. The esophageal, tympanic, rectal, pulmonary artery, bladder, bone marrow, kidney, brain, blood, lung, and airway temperatures were recorded continuously. The thermal dose, thermal exchange, metabolic heat production, heat loss to the environment, the change in body heat, and the thermal isoeffect dose were studied at 15-minute intervals. Results. VV-PISH increased heart rate and cardiac output and caused a redistribution of blood flow favoring the thoracoabdominal organs. Greatest thermal exchange occurred during the heating phase (total 2,162 ± 143 kJ), metabolic heat production contributed in all phases (274 ± 9 kJ), the greatest change in body heat occurred during heating (1,310 ± 309 kJ) with a total delivered thermal dose of 298 ± 21 kJ, and the total whole body thermal isoeffect dose at 100 ± 5 minutes. Conclusions. VV-PISH is feasible, is capable of transferring sufficient heat, causes a redistribution of blood flow favoring the thoracoabdominal organs, and facilitates calculation of whole-body and regional thermal isoeffect doses. (C) 2000 by The Society of Thoracic Surgeons.",
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    AU - Zwischenberger, Joseph B.

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    N2 - Background. Thermal events during extracorporeal venovenous perfusion-induced systemic hyperthermia (VV-PISH) were studied and related to determination of whole-body and regional thermal isoeffect doses. Methods. Swine (n = 6, 77 ± 4.5 kg) were heated to a target temperature of 43°C for 120 minutes using VV-PISH. Colored microspheres were injected during pre-heat, heat induction, maintenance, cool down, and after decannulation. The esophageal, tympanic, rectal, pulmonary artery, bladder, bone marrow, kidney, brain, blood, lung, and airway temperatures were recorded continuously. The thermal dose, thermal exchange, metabolic heat production, heat loss to the environment, the change in body heat, and the thermal isoeffect dose were studied at 15-minute intervals. Results. VV-PISH increased heart rate and cardiac output and caused a redistribution of blood flow favoring the thoracoabdominal organs. Greatest thermal exchange occurred during the heating phase (total 2,162 ± 143 kJ), metabolic heat production contributed in all phases (274 ± 9 kJ), the greatest change in body heat occurred during heating (1,310 ± 309 kJ) with a total delivered thermal dose of 298 ± 21 kJ, and the total whole body thermal isoeffect dose at 100 ± 5 minutes. Conclusions. VV-PISH is feasible, is capable of transferring sufficient heat, causes a redistribution of blood flow favoring the thoracoabdominal organs, and facilitates calculation of whole-body and regional thermal isoeffect doses. (C) 2000 by The Society of Thoracic Surgeons.

    AB - Background. Thermal events during extracorporeal venovenous perfusion-induced systemic hyperthermia (VV-PISH) were studied and related to determination of whole-body and regional thermal isoeffect doses. Methods. Swine (n = 6, 77 ± 4.5 kg) were heated to a target temperature of 43°C for 120 minutes using VV-PISH. Colored microspheres were injected during pre-heat, heat induction, maintenance, cool down, and after decannulation. The esophageal, tympanic, rectal, pulmonary artery, bladder, bone marrow, kidney, brain, blood, lung, and airway temperatures were recorded continuously. The thermal dose, thermal exchange, metabolic heat production, heat loss to the environment, the change in body heat, and the thermal isoeffect dose were studied at 15-minute intervals. Results. VV-PISH increased heart rate and cardiac output and caused a redistribution of blood flow favoring the thoracoabdominal organs. Greatest thermal exchange occurred during the heating phase (total 2,162 ± 143 kJ), metabolic heat production contributed in all phases (274 ± 9 kJ), the greatest change in body heat occurred during heating (1,310 ± 309 kJ) with a total delivered thermal dose of 298 ± 21 kJ, and the total whole body thermal isoeffect dose at 100 ± 5 minutes. Conclusions. VV-PISH is feasible, is capable of transferring sufficient heat, causes a redistribution of blood flow favoring the thoracoabdominal organs, and facilitates calculation of whole-body and regional thermal isoeffect doses. (C) 2000 by The Society of Thoracic Surgeons.

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