Ventilator-associated pneumonia in patients with adult respiratory distress syndrome: CT evaluation

Helen T. Winer-Muram, Robert M. Steiner, Jud W. Gurney, Rosita Shah, S. Gregory Jennings, Kristopher L. Arheart, Mahmoud A. Eltorky, G. Umberto Meduri

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

PURPOSE: To determine the diagnostic accuracy of computed tomography (CT) for pneumonia in patients with adult respiratory distress syndrome (ARDS). MATERIALS AND METHODS: CT scans were obtained within 1 week of bronchoscopic sampling in 31 patients receiving mechanical ventilation for ARDS for more than 48 hours. Of 11 patients with pneumonia, five developed symptoms less than 11 days after the onset of ARDS (early ARDS). CT scans were rated for pneumonia independently by four radiologists who were unaware of the clinical diagnosis. Diagnostic accuracy was defined by means of the area under the receiver operating characteristic curve, or A(z). RESULTS: Diagnostic accuracy for pneumonia was fair (A(z) = 0.69 ± 0.04 [standard error]) owing to 70% true-negative ratings (vs 59% true-positive ratings). The generalizability coefficient were as good (0.79). No single CT finding was significantly different for the presence of pneumonia. Nondependent opacities predominated in 10 (91%) of 11 patients with pneumonia and 12 (60%) of 20 without pneumonia. Nondependent opacities predominated in nine (56%) of 16 patients with early ARDS and 13 (87%) of 15 with late ARDS. CONCLUSION: CT has fair diagnostic accuracy for ventilator-associated pneumonia in patients with ARDS owing primarily to identification of patients without pneumonia. No single CT sign was significantly different for pneumonia, but dependent atelectasis was more common in patients with early ARDs without pneumonia.

Original languageEnglish (US)
Pages (from-to)193-199
Number of pages7
JournalRadiology
Volume208
Issue number1
StatePublished - Jul 1998
Externally publishedYes

Fingerprint

Ventilator-Associated Pneumonia
Adult Respiratory Distress Syndrome
Pneumonia
Tomography
Pulmonary Atelectasis
Artificial Respiration
ROC Curve

Keywords

  • Lung, assisted ventilation
  • Lung, CT, 60.1211
  • Lung, infection, 60.21
  • Respiratory distress syndrome, adult (ARDS), 60.413

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Winer-Muram, H. T., Steiner, R. M., Gurney, J. W., Shah, R., Jennings, S. G., Arheart, K. L., ... Meduri, G. U. (1998). Ventilator-associated pneumonia in patients with adult respiratory distress syndrome: CT evaluation. Radiology, 208(1), 193-199.

Ventilator-associated pneumonia in patients with adult respiratory distress syndrome : CT evaluation. / Winer-Muram, Helen T.; Steiner, Robert M.; Gurney, Jud W.; Shah, Rosita; Jennings, S. Gregory; Arheart, Kristopher L.; Eltorky, Mahmoud A.; Meduri, G. Umberto.

In: Radiology, Vol. 208, No. 1, 07.1998, p. 193-199.

Research output: Contribution to journalArticle

Winer-Muram, HT, Steiner, RM, Gurney, JW, Shah, R, Jennings, SG, Arheart, KL, Eltorky, MA & Meduri, GU 1998, 'Ventilator-associated pneumonia in patients with adult respiratory distress syndrome: CT evaluation', Radiology, vol. 208, no. 1, pp. 193-199.
Winer-Muram HT, Steiner RM, Gurney JW, Shah R, Jennings SG, Arheart KL et al. Ventilator-associated pneumonia in patients with adult respiratory distress syndrome: CT evaluation. Radiology. 1998 Jul;208(1):193-199.
Winer-Muram, Helen T. ; Steiner, Robert M. ; Gurney, Jud W. ; Shah, Rosita ; Jennings, S. Gregory ; Arheart, Kristopher L. ; Eltorky, Mahmoud A. ; Meduri, G. Umberto. / Ventilator-associated pneumonia in patients with adult respiratory distress syndrome : CT evaluation. In: Radiology. 1998 ; Vol. 208, No. 1. pp. 193-199.
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