Ventricular ectopic activity with diuretic therapy

O. B. Holland, L. Kuhnert, J. Pollard, M. Padia, R. J. Anderson, G. Blomqvist

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The arrhythmogenic potential of diuretic-induced hypokalemia in patients with uncomplicated hypertension has been controversial. Thirty-two hypertensive patients with previous diuretic-induced hypokalemia, normal 24-hour ambulatory ECG monitoring, and normal exercise testing were treated with 100 mg hydrochlorothiazide (HCTZ) daily (Group 1) to induce hypokalemia or with a combination of HCTZ with amiloride (Group 2) to attempt to maintain plasma potassium levels in the normal range during diuretic therapy. Those Group 1 patients (Group 1A) with increased ventricular ectopic activity (VEA) during HCTZ therapy were subsequently potassium-repleted with amiloride and with supplemental potassium chloride to evaluate the effect of these treatments on VEA. One Group 1 patient died suddenly after 12 days of HCTZ therapy. Autopsy findings suggested an arrhythmic death. Six Group 1 patients who had increased VEA with HCTZ treatment had reductions in VEA with amiloride or supplemental potassium chloride. Group 2 patients did not have a significant increase in VEA. Thus, diuretic therapy appears to cause VEA primarily by electrolyte changes that are induced.

Original languageEnglish (US)
Pages (from-to)380-385
Number of pages6
JournalAmerican Journal of Hypertension
Volume1
Issue number4 Part I
StatePublished - 1988

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Diuretics
Hydrochlorothiazide
Hypokalemia
Potassium Chloride
Amiloride
Potassium
Therapeutics
Ambulatory Monitoring
Electrolytes
Autopsy
Electrocardiography
Reference Values
Exercise
Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Holland, O. B., Kuhnert, L., Pollard, J., Padia, M., Anderson, R. J., & Blomqvist, G. (1988). Ventricular ectopic activity with diuretic therapy. American Journal of Hypertension, 1(4 Part I), 380-385.

Ventricular ectopic activity with diuretic therapy. / Holland, O. B.; Kuhnert, L.; Pollard, J.; Padia, M.; Anderson, R. J.; Blomqvist, G.

In: American Journal of Hypertension, Vol. 1, No. 4 Part I, 1988, p. 380-385.

Research output: Contribution to journalArticle

Holland, OB, Kuhnert, L, Pollard, J, Padia, M, Anderson, RJ & Blomqvist, G 1988, 'Ventricular ectopic activity with diuretic therapy', American Journal of Hypertension, vol. 1, no. 4 Part I, pp. 380-385.
Holland OB, Kuhnert L, Pollard J, Padia M, Anderson RJ, Blomqvist G. Ventricular ectopic activity with diuretic therapy. American Journal of Hypertension. 1988;1(4 Part I):380-385.
Holland, O. B. ; Kuhnert, L. ; Pollard, J. ; Padia, M. ; Anderson, R. J. ; Blomqvist, G. / Ventricular ectopic activity with diuretic therapy. In: American Journal of Hypertension. 1988 ; Vol. 1, No. 4 Part I. pp. 380-385.
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