Vertical transmission of zika virus in aedes aegypti mosquitoes

Saravanan Thangamani, Jing Huang, Charles E. Hart, Hilda Guzman, Robert B. Tesh

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Previous experimental studies have demonstrated that a number of mosquito-borne flavivirus pathogens are vertically transmitted in their insect vectors, providing a mechanism for these arboviruses to persist during adverse climatic conditions or in the absence of a susceptible vertebrate host. In this study, designed to test whether Zika virus (ZIKV) could be vertically transmitted, female Aedes aegypti and Aedes albopictus were injected with ZIKV, and their F1 adult progeny were tested for ZIKV infection. Six of 69 Ae. aegypti pools, comprised of a total of 1,738 F1 adults, yielded ZIKV upon culture, giving a minimum filial infection rate of 1:290. In contrast, none of 803 F1 Ae. albopictus adults (32 pools) yielded ZIKV. The MFIR for Ae. aegypti was comparable to MFIRs reported for other flaviviruses in mosquitoes, including dengue, Japanese encephalitis, yellow fever, West Nile, and St. Louis encephalitis viruses. The results suggest that vertical transmission may provide a potential mechanism for the virus to survive during adverse conditions.

Original languageEnglish (US)
Pages (from-to)1169-1173
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume95
Issue number5
DOIs
StatePublished - Nov 1 2016

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Aedes
Culicidae
Flavivirus
St. Louis Encephalitis Viruses
Insect Vectors
Japanese Encephalitis
Yellow Fever
Arboviruses
Dengue
Vertebrates
Viruses
Zika Virus
Infection

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Vertical transmission of zika virus in aedes aegypti mosquitoes. / Thangamani, Saravanan; Huang, Jing; Hart, Charles E.; Guzman, Hilda; Tesh, Robert B.

In: American Journal of Tropical Medicine and Hygiene, Vol. 95, No. 5, 01.11.2016, p. 1169-1173.

Research output: Contribution to journalArticle

Thangamani, Saravanan ; Huang, Jing ; Hart, Charles E. ; Guzman, Hilda ; Tesh, Robert B. / Vertical transmission of zika virus in aedes aegypti mosquitoes. In: American Journal of Tropical Medicine and Hygiene. 2016 ; Vol. 95, No. 5. pp. 1169-1173.
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