Vesicular stomatitis virus-based vaccines protect nonhuman primates against aerosol challenge with Ebola and Marburg viruses

Thomas W. Geisbert, Kathleen M. Daddario-DiCaprio, Joan B. Geisbert, Douglas S. Reed, Friederike Feldmann, Allen Grolla, Ute Ströher, Elizabeth A. Fritz, Lisa E. Hensley, Steven M. Jones, Heinz Feldmann

Research output: Contribution to journalArticle

142 Scopus citations

Abstract

Considerable progress has been made over the last decade in developing candidate preventive vaccines that can protect nonhuman primates against Ebola and Marburg viruses. A vaccine based on recombinant vesicular stomatitis virus (VSV) seems to be particularly robust as it can also confer protection when administered as a postexposure treatment. While filoviruses are not thought to be transmitted by aerosol in nature the inhalation route is among the most likely portals of entry in the setting of a bioterrorist event. At present, all candidate filoviral vaccines have been evaluated against parenteral challenges but none have been tested against an aerosol exposure. Here, we evaluated our recombinant VSV-based Zaire ebolavirus (ZEBOV) and Marburg virus (MARV) vaccines against aerosol challenge in cynomolgus macaques. All monkeys vaccinated with a VSV vector expressing the glycoprotein of ZEBOV were completely protected against an aerosol exposure of ZEBOV. Likewise, all monkeys vaccinated with a VSV vector expressing the glycoprotein of MARV were completely protected against an aerosol exposure of MARV. All control animals challenged by the aerosol route with either ZEBOV or MARV succumbed. Interestingly, disease in control animals appeared to progress slower than previously seen in macaques exposed to comparable doses by intramuscular injection.

Original languageEnglish (US)
Pages (from-to)6894-6900
Number of pages7
JournalVaccine
Volume26
Issue number52
DOIs
StatePublished - Dec 9 2008
Externally publishedYes

Keywords

  • Aerosol
  • Ebola virus
  • Filovirus
  • Marburg virus
  • Nonhuman primates
  • Vaccines

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Vesicular stomatitis virus-based vaccines protect nonhuman primates against aerosol challenge with Ebola and Marburg viruses'. Together they form a unique fingerprint.

  • Cite this

    Geisbert, T. W., Daddario-DiCaprio, K. M., Geisbert, J. B., Reed, D. S., Feldmann, F., Grolla, A., Ströher, U., Fritz, E. A., Hensley, L. E., Jones, S. M., & Feldmann, H. (2008). Vesicular stomatitis virus-based vaccines protect nonhuman primates against aerosol challenge with Ebola and Marburg viruses. Vaccine, 26(52), 6894-6900. https://doi.org/10.1016/j.vaccine.2008.09.082