Vesicular stomatitis virus–based vaccines against lassa and ebola viruses

Andrea Marzi; Friederike Feldmann; Thomas W. Geisbert; Heinz Feldmann; David Safronetz

doi:10.3201/eid2102.141649

Vesicular stomatitis virus–based vaccines against lassa and ebola viruses

Andrea Marzi
, Friederike Feldmann
, Thomas W. Geisbert
, Heinz Feldmann
, David Safronetz

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)-based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with VSV-based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines against divergent viral pathogens, even when preexisting immunity to the vaccine vector is present.

Original language	English (US)
Pages (from-to)	305-307
Number of pages	3
Journal	Emerging infectious diseases
Volume	21
Issue number	2
DOIs	https://doi.org/10.3201/eid2102.141649
State	Published - 2015

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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10.3201/eid2102.141649

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title = "Vesicular stomatitis virus–based vaccines against lassa and ebola viruses",

abstract = "We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)-based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with VSV-based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines against divergent viral pathogens, even when preexisting immunity to the vaccine vector is present.",

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AU - Marzi, Andrea

AU - Feldmann, Friederike

AU - Geisbert, Thomas W.

AU - Feldmann, Heinz

AU - Safronetz, David

PY - 2015

Y1 - 2015

N2 - We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)-based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with VSV-based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines against divergent viral pathogens, even when preexisting immunity to the vaccine vector is present.

AB - We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)-based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with VSV-based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines against divergent viral pathogens, even when preexisting immunity to the vaccine vector is present.

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UR - https://www.scopus.com/pages/publications/84921818775#tab=citedBy

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DO - 10.3201/eid2102.141649

M3 - Article

C2 - 25625358

AN - SCOPUS:84921818775

SN - 1080-6040

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SP - 305

EP - 307

JO - Emerging infectious diseases

JF - Emerging infectious diseases

IS - 2

ER -

Vesicular stomatitis virus–based vaccines against lassa and ebola viruses

Abstract

ASJC Scopus subject areas

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