Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways

Ricardo Rajsbaum, Adolfo García-Sastre

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

Early innate and cell-intrinsic responses are essential to protect host cells against pathogens. In turn, viruses have developed sophisticated mechanisms to establish productive infections by counteracting host innate immune responses. Increasing evidence indicates that these antiviral factors may have a dual role by directly inhibiting viral replication as well as by sensing and transmitting signals to induce antiviral cytokines. Recent studies have pointed at new, unappreciated mechanisms of viral evasion of host innate protective responses including manipulating the host ubiquitin (Ub) system. Virus-mediated inhibition of antiviral factors by Ub-dependent degradation is emerging as a crucial mechanism for evading the antiviral response. In addition, recent studies have uncovered new mechanisms by which virus-encoded proteins inhibit Ub and Ub-like (Ubl) modification of host proteins involved in innate immune signaling pathways. Here we discuss recent findings and novel strategies that viruses have developed to counteract these early innate antiviral defenses.

Original languageEnglish (US)
Pages (from-to)421-429
Number of pages9
JournalTrends in Microbiology
Volume21
Issue number8
DOIs
StatePublished - Aug 2013

Keywords

  • Antiviral
  • Evasion of innate immunity
  • Restriction factors
  • Ubiquitin system

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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