Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil

Tauyne Menegaldo Pinheiro, Mânlio Tasso de Oliveira Mota, Aripuanã Sakurada Aranha Watanabe, Joice Matos Biselli-Périco, Betânia Paiva Drumond, Milene Rocha Ribeiro, Danila Vedovello, João Pessoa Araújo, Paulo Filemon Paolucci Pimenta, Bárbara Aparecida Chaves, Mayara Marques Carneiro da Silva, Izabella Cristina Andrade Batista, Michelle Premazzi Papa, Lana Monteiro Meuren, Carolina Gonçalves de Oliveira Lucas, Flavio Lemos Matassoli, Laura Helena Vega Gonzales Gil, Adriana Bozzi, Carlos Eduardo Calzavara-Silva, Luciana Barros de Arruda & 4 others Danielle da Glória de Souza, Mauro Martins Teixeira, Nikos Vasilakis, Maurício Lacerda Nogueira

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In São José do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the dominant circulating lineage even after the introduction of the L1 lineage. We investigated viral fitness and immunogenicity of the L1 and L6 lineages and which factors interfered with the dynamics of DENV epidemics. The results showed a more efficient replicative fitness of L1 over L6 in mosquitoes and in human and non-human primate cell lines. Infections by the L6 lineage were associated with reduced antigenicity, weak B and T cell stimulation and weak host immune system interactions, which were associated with higher viremia. Our data, therefore, demonstrate that reduced viral immunogenicity and consequent greater viremia determined the increased epidemiological fitness of DENV-1 L6 lineage in São José do Rio Preto.

Original languageEnglish (US)
Article numbere0006525
JournalPLoS Neglected Tropical Diseases
Volume12
Issue number5
DOIs
StatePublished - May 29 2018

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Dengue Virus
Virus Diseases
Brazil
Viremia
Genotype
Culicidae
Primates
Immune System
B-Lymphocytes
T-Lymphocytes
Cell Line
Infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Pinheiro, T. M., Mota, M. T. D. O., Watanabe, A. S. A., Biselli-Périco, J. M., Drumond, B. P., Ribeiro, M. R., ... Nogueira, M. L. (2018). Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil. PLoS Neglected Tropical Diseases, 12(5), [e0006525]. https://doi.org/10.1371/journal.pntd.0006525

Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil. / Pinheiro, Tauyne Menegaldo; Mota, Mânlio Tasso de Oliveira; Watanabe, Aripuanã Sakurada Aranha; Biselli-Périco, Joice Matos; Drumond, Betânia Paiva; Ribeiro, Milene Rocha; Vedovello, Danila; Araújo, João Pessoa; Pimenta, Paulo Filemon Paolucci; Chaves, Bárbara Aparecida; Silva, Mayara Marques Carneiro da; Batista, Izabella Cristina Andrade; Papa, Michelle Premazzi; Meuren, Lana Monteiro; Lucas, Carolina Gonçalves de Oliveira; Matassoli, Flavio Lemos; Gil, Laura Helena Vega Gonzales; Bozzi, Adriana; Calzavara-Silva, Carlos Eduardo; Arruda, Luciana Barros de; Souza, Danielle da Glória de; Teixeira, Mauro Martins; Vasilakis, Nikos; Nogueira, Maurício Lacerda.

In: PLoS Neglected Tropical Diseases, Vol. 12, No. 5, e0006525, 29.05.2018.

Research output: Contribution to journalArticle

Pinheiro, TM, Mota, MTDO, Watanabe, ASA, Biselli-Périco, JM, Drumond, BP, Ribeiro, MR, Vedovello, D, Araújo, JP, Pimenta, PFP, Chaves, BA, Silva, MMCD, Batista, ICA, Papa, MP, Meuren, LM, Lucas, CGDO, Matassoli, FL, Gil, LHVG, Bozzi, A, Calzavara-Silva, CE, Arruda, LBD, Souza, DDGD, Teixeira, MM, Vasilakis, N & Nogueira, ML 2018, 'Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil', PLoS Neglected Tropical Diseases, vol. 12, no. 5, e0006525. https://doi.org/10.1371/journal.pntd.0006525
Pinheiro TM, Mota MTDO, Watanabe ASA, Biselli-Périco JM, Drumond BP, Ribeiro MR et al. Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil. PLoS Neglected Tropical Diseases. 2018 May 29;12(5). e0006525. https://doi.org/10.1371/journal.pntd.0006525
Pinheiro, Tauyne Menegaldo ; Mota, Mânlio Tasso de Oliveira ; Watanabe, Aripuanã Sakurada Aranha ; Biselli-Périco, Joice Matos ; Drumond, Betânia Paiva ; Ribeiro, Milene Rocha ; Vedovello, Danila ; Araújo, João Pessoa ; Pimenta, Paulo Filemon Paolucci ; Chaves, Bárbara Aparecida ; Silva, Mayara Marques Carneiro da ; Batista, Izabella Cristina Andrade ; Papa, Michelle Premazzi ; Meuren, Lana Monteiro ; Lucas, Carolina Gonçalves de Oliveira ; Matassoli, Flavio Lemos ; Gil, Laura Helena Vega Gonzales ; Bozzi, Adriana ; Calzavara-Silva, Carlos Eduardo ; Arruda, Luciana Barros de ; Souza, Danielle da Glória de ; Teixeira, Mauro Martins ; Vasilakis, Nikos ; Nogueira, Maurício Lacerda. / Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil. In: PLoS Neglected Tropical Diseases. 2018 ; Vol. 12, No. 5.
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