Viral load and acute otitis media development after human metapneumovirus upper respiratory tract infection

Johanna Nokso-Koivisto, Richard B. Pyles, Aaron L. Miller, Janak A. Patel, Michael Loeffelholz, Tasnee Chonmaitree

Research output: Contribution to journalArticle

12 Scopus citations


The role of human metapneumovirus (hMPV) in acute otitis media complicating upper respiratory tract infection (URI) was studied. Nasopharyngeal specimens from 700 URI episodes in 200 children were evaluated; 47 (7%) were positive for hMPV, 25 (3.6%) with hMPV as the only virus. Overall, 24% of URI episodes with hMPV only were complicated by acute otitis media, which was the lowest rate compared with other respiratory viruses. hMPV viral load was significantly higher in children with fever, but there was no difference in viral load in children with hMPV-positive URI with or without acute otitis media complication.

Original languageEnglish (US)
Pages (from-to)763-766
Number of pages4
JournalPediatric Infectious Disease Journal
Issue number7
StatePublished - Jul 1 2012



  • Acute otitis media
  • Human metapneumovirus
  • Upper respiratory tract infection
  • Viral load

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this