TY - JOUR
T1 - Viral metagenomics, protein structure, and reverse genetics
T2 - Key strategies for investigating coronaviruses
AU - Johnson, Bryan A.
AU - Graham, Rachel L.
AU - Menachery, Vineet D.
N1 - Funding Information:
Research in this manuscript was supported by grants from the National Institute of Allergy & Infectious Disease and the National Institute of Aging of the NIH under awards U19 AI109761 (RLG), U19AI100625 (VDM), and R00AG049092 (VDM). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/4
Y1 - 2018/4
N2 - Viral metagenomics, modeling of protein structure, and manipulation of viral genetics are key approaches that have laid the foundations of our understanding of coronavirus biology. In this review, we discuss the major advances each method has provided and discuss how future studies should leverage these strategies synergistically to answer novel questions.
AB - Viral metagenomics, modeling of protein structure, and manipulation of viral genetics are key approaches that have laid the foundations of our understanding of coronavirus biology. In this review, we discuss the major advances each method has provided and discuss how future studies should leverage these strategies synergistically to answer novel questions.
UR - http://www.scopus.com/inward/record.url?scp=85039552156&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85039552156&partnerID=8YFLogxK
U2 - 10.1016/j.virol.2017.12.009
DO - 10.1016/j.virol.2017.12.009
M3 - Article
C2 - 29279138
AN - SCOPUS:85039552156
SN - 0042-6822
VL - 517
SP - 30
EP - 37
JO - Virology
JF - Virology
ER -