Abstract
An electron microscopic study of Coxsackievirus B3-infected newborn mice revealed pathological changes in both the endocrine and exocrine portions of the pancreas. Damage ranged from a focal degeneration in which small areas of individual cells were affected to a widespread necrosis and inflammation in which entire acini and islets were so changed that identification of individual cell types was difficult. Compound membrane-vesicle complexes typical of picornavirus infection and virus particles in various arrays were observed in the acinar cells and macrophages. Fibrosis of the islets and a thickening of the basal laminae of associated capillaries were noted also. Comparisons were made to the pancreatitis caused by this and other group B Coxsackieviruses in both human and experimental animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 206-219 |
| Number of pages | 14 |
| Journal | Experimental and Molecular Pathology |
| Volume | 17 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1972 |
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ASJC Scopus subject areas
- Clinical Biochemistry
- Molecular Biology
- Pathology and Forensic Medicine
Cite this
Viral pancreatitis : Ultrastructural pathological effects of coxsackievirus B3 infection in newborn mouse pancreas. / Harrison, Alyne K.; Bauer, Sally P.; Murphy, Frederick A.
In: Experimental and Molecular Pathology, Vol. 17, No. 2, 1972, p. 206-219.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Viral pancreatitis
T2 - Ultrastructural pathological effects of coxsackievirus B3 infection in newborn mouse pancreas
AU - Harrison, Alyne K.
AU - Bauer, Sally P.
AU - Murphy, Frederick A.
PY - 1972
Y1 - 1972
N2 - An electron microscopic study of Coxsackievirus B3-infected newborn mice revealed pathological changes in both the endocrine and exocrine portions of the pancreas. Damage ranged from a focal degeneration in which small areas of individual cells were affected to a widespread necrosis and inflammation in which entire acini and islets were so changed that identification of individual cell types was difficult. Compound membrane-vesicle complexes typical of picornavirus infection and virus particles in various arrays were observed in the acinar cells and macrophages. Fibrosis of the islets and a thickening of the basal laminae of associated capillaries were noted also. Comparisons were made to the pancreatitis caused by this and other group B Coxsackieviruses in both human and experimental animals.
AB - An electron microscopic study of Coxsackievirus B3-infected newborn mice revealed pathological changes in both the endocrine and exocrine portions of the pancreas. Damage ranged from a focal degeneration in which small areas of individual cells were affected to a widespread necrosis and inflammation in which entire acini and islets were so changed that identification of individual cell types was difficult. Compound membrane-vesicle complexes typical of picornavirus infection and virus particles in various arrays were observed in the acinar cells and macrophages. Fibrosis of the islets and a thickening of the basal laminae of associated capillaries were noted also. Comparisons were made to the pancreatitis caused by this and other group B Coxsackieviruses in both human and experimental animals.
UR - http://www.scopus.com/inward/record.url?scp=0015418010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015418010&partnerID=8YFLogxK
U2 - 10.1016/0014-4800(72)90070-6
DO - 10.1016/0014-4800(72)90070-6
M3 - Article
C2 - 4116327
AN - SCOPUS:0015418010
VL - 17
SP - 206
EP - 219
JO - Experimental and Molecular Pathology
JF - Experimental and Molecular Pathology
SN - 0014-4800
IS - 2
ER -