Viral pancreatitis

Ultrastructural pathological effects of coxsackievirus B3 infection in newborn mouse pancreas

Alyne K. Harrison, Sally P. Bauer, Frederick A. Murphy

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

An electron microscopic study of Coxsackievirus B3-infected newborn mice revealed pathological changes in both the endocrine and exocrine portions of the pancreas. Damage ranged from a focal degeneration in which small areas of individual cells were affected to a widespread necrosis and inflammation in which entire acini and islets were so changed that identification of individual cell types was difficult. Compound membrane-vesicle complexes typical of picornavirus infection and virus particles in various arrays were observed in the acinar cells and macrophages. Fibrosis of the islets and a thickening of the basal laminae of associated capillaries were noted also. Comparisons were made to the pancreatitis caused by this and other group B Coxsackieviruses in both human and experimental animals.

Original languageEnglish (US)
Pages (from-to)206-219
Number of pages14
JournalExperimental and Molecular Pathology
Volume17
Issue number2
DOIs
StatePublished - 1972

Fingerprint

Coxsackievirus Infections
Macrophages
Viruses
Pancreatitis
Picornaviridae Infections
Pancreas
Animals
Membranes
Human Enterovirus B
Exocrine Pancreas
Electrons
Enterovirus
Acinar Cells
Basement Membrane
Virion
Fibrosis
Necrosis
Inflammation

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

Cite this

Viral pancreatitis : Ultrastructural pathological effects of coxsackievirus B3 infection in newborn mouse pancreas. / Harrison, Alyne K.; Bauer, Sally P.; Murphy, Frederick A.

In: Experimental and Molecular Pathology, Vol. 17, No. 2, 1972, p. 206-219.

Research output: Contribution to journalArticle

Harrison, Alyne K. ; Bauer, Sally P. ; Murphy, Frederick A. / Viral pancreatitis : Ultrastructural pathological effects of coxsackievirus B3 infection in newborn mouse pancreas. In: Experimental and Molecular Pathology. 1972 ; Vol. 17, No. 2. pp. 206-219.
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