Viral pancreatitis: Ultrastructural pathological effects of coxsackievirus B3 infection in newborn mouse pancreas

Alyne K. Harrison, Sally P. Bauer, Frederick A. Murphy

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

An electron microscopic study of Coxsackievirus B3-infected newborn mice revealed pathological changes in both the endocrine and exocrine portions of the pancreas. Damage ranged from a focal degeneration in which small areas of individual cells were affected to a widespread necrosis and inflammation in which entire acini and islets were so changed that identification of individual cell types was difficult. Compound membrane-vesicle complexes typical of picornavirus infection and virus particles in various arrays were observed in the acinar cells and macrophages. Fibrosis of the islets and a thickening of the basal laminae of associated capillaries were noted also. Comparisons were made to the pancreatitis caused by this and other group B Coxsackieviruses in both human and experimental animals.

Original languageEnglish (US)
Pages (from-to)206-219
Number of pages14
JournalExperimental and Molecular Pathology
Volume17
Issue number2
DOIs
StatePublished - Oct 1972

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

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